Abstract
A GC assay method for haloperidol reductase was developed. Haloperidol reductase was present in guinea pig liver cytosol as well as in the microsomes, while in human liver only the cytosol exhibited the activity. The reductase activity was NADPH dependent for both species. Known substrates of ketone reductase such as menadione, daunorubicin, and ethacrynic acid strongly inhibited the human haloperidol reductase. The haloperidol reductase showed characteristics of ketone reductase.
DMD articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.
In this issue
Jump to section
Related Articles
Cited By...
Similar Articles
Advertisement