Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science (Y.K.), Tottori University, Tottori, Japan; and Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan (S.I., S.Og., T.U., S.Oh.)

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science (Y.K.), Tottori University, Tottori, Japan; and Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan (S.I., S.Og., T.U., S.Oh.)

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science (Y.K.), Tottori University, Tottori, Japan; and Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan (S.I., S.Og., T.U., S.Oh.)

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science (Y.K.), Tottori University, Tottori, Japan; and Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan (S.I., S.Og., T.U., S.Oh.)

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science (Y.K.), Tottori University, Tottori, Japan; and Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan (S.I., S.Og., T.U., S.Oh.)

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science (Y.K.), Tottori University, Tottori, Japan; and Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan (S.I., S.Og., T.U., S.Oh.)

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science (Y.K.), Tottori University, Tottori, Japan; and Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan (S.I., S.Og., T.U., S.Oh.)

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science (Y.K.), Tottori University, Tottori, Japan; and Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan (S.I., S.Og., T.U., S.Oh.)

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science (Y.K.), Tottori University, Tottori, Japan; and Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan (S.I., S.Og., T.U., S.Oh.)

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science (Y.K.), Tottori University, Tottori, Japan; and Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan (S.I., S.Og., T.U., S.Oh.)

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science (Y.K.), Tottori University, Tottori, Japan; and Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan (S.I., S.Og., T.U., S.Oh.)

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science (Y.K.), Tottori University, Tottori, Japan; and Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan (S.I., S.Og., T.U., S.Oh.)

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science (Y.K.), Tottori University, Tottori, Japan; and Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan (S.I., S.Og., T.U., S.Oh.)

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science (Y.K.), Tottori University, Tottori, Japan; and Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan (S.I., S.Og., T.U., S.Oh.)

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science (Y.K.), Tottori University, Tottori, Japan; and Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan (S.I., S.Og., T.U., S.Oh.)

Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan (Y.Y., K.Ko., F.O., G.M., H.A., K.C.); Chromosome Engineering Research Center (N.K., K.Ka., S.A., S.T., M.O., Y.K.) and Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science (Y.K.), Tottori University, Tottori, Japan; and Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan (S.I., S.Og., T.U., S.Oh.)