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Abstract

Use of the NIH shift to determine the relative contribution of competing pathways of aniline metabolism in the rat.

S J Grossman and D J Jollow
Drug Metabolism and Disposition November 1986, 14 (6) 689-691;
S J Grossman
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D J Jollow
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Abstract

The retention of tritium in urinary p-aminophenol and p-hydroxyacetanilide was determined following the administration of p-3H-aniline or p-3H-acetanilide to rats. When p-3H-aniline (1.5 mmol/kg, ip) was given to rats, the retention of tritium in urinary p-aminophenol and p-hydroxyacetanilide was 15% and 38%, respectively. Similar results were obtained following the administration of p-3H-acetanilide (1.5 mmol/kg). However, when p-3H-acetanilide was given to rats which had been pretreated with bis-(p-nitrophenyl)phosphate to block the deacetylation capacity, urinary 3H-p-hydroxyacetanilide was recovered with 53% retention of tritium. The data indicate that, at the doses studied: the primary route of aniline metabolism is via sequential acetylation and hydroxylation, and deacetylation plays a significant role in the disposition of acetanilide.

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Drug Metabolism and Disposition
Vol. 14, Issue 6
1 Nov 1986
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Abstract

Use of the NIH shift to determine the relative contribution of competing pathways of aniline metabolism in the rat.

S J Grossman and D J Jollow
Drug Metabolism and Disposition November 1, 1986, 14 (6) 689-691;

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Abstract

Use of the NIH shift to determine the relative contribution of competing pathways of aniline metabolism in the rat.

S J Grossman and D J Jollow
Drug Metabolism and Disposition November 1, 1986, 14 (6) 689-691;
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