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Mechanisms of Enhanced Oral Availability of CYP3A4 Substrates by Grapefruit Constituents

Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins

Phyllissa Schmiedlin-Ren, David J. Edwards, Michael E. Fitzsimmons, Kan He, Kenneth S. Lown, Patrick M. Woster, Atiqur Rahman, Kenneth E. Thummel, Jeannine M. Fisher, Paul F. Hollenberg and Paul B. Watkins
Drug Metabolism and Disposition November 1997, 25 (11) 1228-1233;

Article Information

vol. 25 no. 11 1228-1233
PubMed 
9351897
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 3, 1997
  • Accepted August 5, 1997
  • Published online November 1, 1997.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Phyllissa Schmiedlin-Ren1,
  2. David J. Edwards2,
  3. Michael E. Fitzsimmons1,5,
  4. Kan He4,
  5. Kenneth S. Lown1,
  6. Patrick M. Woster3,
  7. Atiqur Rahman5,
  8. Kenneth E. Thummel6,
  9. Jeannine M. Fisher6,
  10. Paul F. Hollenberg4 and
  11. Paul B. Watkins1
  1. 1Department of Internal Medicine, University of Michigan Medical Center (P.S.-R., M.E.F., K.S.L., P.B.W.); 2Department of Pharmacy Practice (D.J.E.) and 3Pharmaceutical Sciences (P.M.W.), College of Pharmacy and Allied Health Professions, Wayne State University; 4Department of Pharmacology, University of Michigan Medical School (P.F.H., K.H.); 5Division of Clinical Pharmacology, Center for Drug Evaluation and Research, United States Food and Drug Administration (A.R., M.E.F.); 6Department of Pharmaceutics, University of Washington (K.E.T., J.M.F.)
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    Rapid CommunicationAccelerated Communication

    Mechanisms of Enhanced Oral Availability of CYP3A4 Substrates by Grapefruit Constituents

    Phyllissa Schmiedlin-Ren, David J. Edwards, Michael E. Fitzsimmons, Kan He, Kenneth S. Lown, Patrick M. Woster, Atiqur Rahman, Kenneth E. Thummel, Jeannine M. Fisher, Paul F. Hollenberg and Paul B. Watkins
    Drug Metabolism and Disposition November 1, 1997, 25 (11) 1228-1233;
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