Table of Contents

Articles

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  Correlation between In Vivo and In Vitro Hepatic Uptake of Metabolic Inhibitors of Cytochrome P-450 in Rats

  Katsuhiro Yamano, Koujirou Yamamoto, Hajime Kotaki, Sayuri Takedomi, Hirotami Matsuo, Yasufumi Sawada and Tatsuji Iga

  Drug Metabolism and Disposition November 1999, 27 (11) 1225-1231;
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  Preclinical Pharmacokinetics and Interspecies Scaling of a Novel Vitronectin Receptor Antagonist

  Keith W. Ward, Leonard M. Azzarano, William E. Bondinell, Russell D. Cousins, William F. Huffman, Dalia R. Jakas, Richard M. Keenan, Thomas W. Ku, Dave Lundberg, William H. Miller, Jayme A. Mumaw, Kenneth A. Newlander, Jill L. Pirhalla, Theresa J. Roethke, Kevin L. Salyers, Pamela R. Souder, Gary J. Stelman and Brian R. Smith

  Drug Metabolism and Disposition November 1999, 27 (11) 1232-1241;
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  Effect of a Ligand Selective for Peripheral Benzodiazepine Receptors on the Expression of Rat Hepatic P-450 Cytochromes: Assessment of the Effect In Vivo and in a Hepatocyte Culture System

  Hideyuki Yamada, Yumie Matsuki, Tohru Yamaguchi and Kazuta Oguri

  Drug Metabolism and Disposition November 1999, 27 (11) 1242-1247;
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  Direct Detection of Antipyrine Metabolites in Rat Urine by¹³C Labeling and NMR Spectroscopy

  Kazuki Akira, Eiji Negishi, Chiseko Sakuma and Takao Hashimoto

  Drug Metabolism and Disposition November 1999, 27 (11) 1248-1253;
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  Identification of Human Cytochrome P-450 Isoforms Involved in Metabolism of R(+)- and S(−)-Gallopamil: Utility of In Vitro Disappearance Rate

  Akio Suzuki, Izumi Iida, Fumie Tanaka, Masayuki Akimoto, Kiyomi Fukushima, Masayoshi Tani, Takashi Ishizaki and Kan Chiba

  Drug Metabolism and Disposition November 1999, 27 (11) 1254-1259;
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  Oxidation of Troglitazone to a Quinone-Type Metabolite Catalyzed by Cytochrome P-450 2C8 and P-450 3A4 in Human Liver Microsomes

  Hiroshi Yamazaki, Ayaka Shibata, Mikie Suzuki, Miki Nakajima, Noriaki Shimada, F. Peter Guengerich and Tsuyoshi Yokoi

  Drug Metabolism and Disposition November 1999, 27 (11) 1260-1266;
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  Identification of Metabolites of Octamethylcyclotetrasiloxane (D₄) in Rat Urine

  Sudarsanan Varaprath, Kevin L. Salyers, Kathleen P. Plotzke and Shrenik Nanavati

  Drug Metabolism and Disposition November 1999, 27 (11) 1267-1273;
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  Prediction of Human Liver Microsomal Oxidations of 7-Ethoxycoumarin and Chlorzoxazone with Kinetic Parameters of Recombinant Cytochrome P-450 Enzymes

  Tsutomu Shimada, Fujiko Tsumura and Hiroshi Yamazaki

  Drug Metabolism and Disposition November 1999, 27 (11) 1274-1280;
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  Conjugation of the Enantiomers of Ketotifen to Four Isomeric Quaternary Ammonium Glucuronides in Humans In Vivo and in Liver Microsomes

  Udo Mey, Helmut Wachsmuth and Ursula Breyer-Pfaff

  Drug Metabolism and Disposition November 1999, 27 (11) 1281-1292;
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  Propofol Hydroxylation by Dog Liver Microsomes: Assay Development and Dog Breed Differences

  Michael H. Court, Bonnie L. Hay-Kraus, Dennis W. Hill, Albert J. Kind and David J. Greenblatt

  Drug Metabolism and Disposition November 1999, 27 (11) 1293-1299;
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  Disposition of [G-³H]paclitaxel and Cremophor EL in a Patient with Severely Impaired Renal Function

  Hans Gelderblom, Jaap Verweij, Eric Brouwer, Marrimuthoo Pillay, Peter de Bruijn, Kees Nooter, Gerrit Stoter and Alex Sparreboom

  Drug Metabolism and Disposition November 1999, 27 (11) 1300-1305;
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  Catalysis of Drug Oxidation during Embryogenesis in Human Hepatic Tissues using Imipramine as a Model Substrate

  Hao Chen, Monica R. Brzezinski, Alan G. Fantel and Mont R. Juchau

  Drug Metabolism and Disposition November 1999, 27 (11) 1306-1308;
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  Stereoselective Metabolism of Ifosfamide by Human P-450s 3A4 and 2B6. Favorable Metabolic Properties of R-Enantiomer

  Partha Roy, Olga Tretyakov, Joel Wright and David J. Waxman

  Drug Metabolism and Disposition November 1999, 27 (11) 1309-1318;
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  Identification and Characterization of Efavirenz Metabolites by Liquid Chromatography/Mass Spectrometry and High Field NMR: Species Differences in the Metabolism of Efavirenz

  A. E. Mutlib, H. Chen, G. A. Nemeth, J. A. Markwalder, S. P. Seitz, L. S. Gan and D. D. Christ

  Drug Metabolism and Disposition November 1999, 27 (11) 1319-1333;
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  Cytochrome P-450-Mediated Metabolism of the Individual Enantiomers of the Antidepressant Agent Reboxetine in Human Liver Microsomes

  Larry C. Wienkers, Cecilia Allievi, Michael J. Hauer and Michael A. Wynalda

  Drug Metabolism and Disposition November 1999, 27 (11) 1334-1340;
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  Metabolites of [¹⁴C]-5-(2-Ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetrahydropyridine in Mice, Rats, Dogs, and Humans

  Ellen Bech Christensen, Jan Bruun Andersen, Henrik Pedersen, Klaus Gjervig Jensen and Lars Dalgaard

  Drug Metabolism and Disposition November 1999, 27 (11) 1341-1349;
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  Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

  R. Scott Obach

  Drug Metabolism and Disposition November 1999, 27 (11) 1350-1359;
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  In Vitro and In Vivo Studies on the Metabolism of Tirofiban

  Stanley Vickers, Anthony D. Theoharides, Byron Arison, Suresh K. Balani, Dan Cui, Carol A. Duncan, Joan D. Ellis, Lynn M. Gorham, Stacey L. Polsky, Thomayant Prueksaritanont, Harri G. Ramjit, Donald E. Slaughter and Kamlesh P. Vyas

  Drug Metabolism and Disposition November 1999, 27 (11) 1360-1366;
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  Substance P Receptor Antagonist I: Conversion of Phosphoramidate Prodrug after i.v. Administration to Rats and Dogs

  Su-Er W. Huskey, Debra Luffer-Atlas, Brian J. Dean, Erin M. McGowan, William P. Feeney and Shuet-Hing Lee Chiu

  Drug Metabolism and Disposition November 1999, 27 (11) 1367-1373;