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Research ArticleArticle

Identification of CYP3A4 as the Enzyme Involved in the Mono-N-Dealkylation of Disopyramide Enantiomers in Humans

Hirotoshi Echizen, Michika Tanizaki, Jun Tatsuno, Kan Chiba, Teresa Berwick, Masayoshi Tani, Frank J. Gonzalez and Takashi Ishizaki
Drug Metabolism and Disposition August 2000, 28 (8) 937-944;

Article Information

vol. 28 no. 8 937-944
PubMed 
10901704
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received January 11, 2000
  • Accepted April 19, 2000
  • Published online August 1, 2000.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hirotoshi Echizen1,
  2. Michika Tanizaki2,
  3. Jun Tatsuno3,
  4. Kan Chiba5,
  5. Teresa Berwick4,
  6. Masayoshi Tani,
  7. Frank J. Gonzalez7 and
  8. Takashi Ishizaki6
  1. 1Department of Pharmacotherapy, Meiji Pharmaceutical University (H.E.); 2Department of Pharmaceutical Science, Science University of Tokyo (M.T.); 3Mitsubishi Chemical Corporation (J.T.); 4Division of General Surgery, International Medical Center of Japan (T.B.), Tokyo; 5Laboratory of Biochemical Pharmacology and Toxicology, Chiba University (K.C.), Chiba; 6Department of Pharmacology and Therapeutics, Graduate School of Clinical Pharmacy, Kumamoto University, Kumamoto (T.I.), Japan; and 7Laboratory of Metabolism, National Cancer Institute, National Institute of Health, Bethesda, Maryand (F.J.G.)
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    Research ArticleArticle

    Identification of CYP3A4 as the Enzyme Involved in the Mono-N-Dealkylation of Disopyramide Enantiomers in Humans

    Hirotoshi Echizen, Michika Tanizaki, Jun Tatsuno, Kan Chiba, Teresa Berwick, Masayoshi Tani, Frank J. Gonzalez and Takashi Ishizaki
    Drug Metabolism and Disposition August 1, 2000, 28 (8) 937-944;
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