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Research ArticleArticle

Multisite Kinetic Models for CYP3A4: Simultaneous Activation and Inhibition of Diazepam and Testosterone Metabolism

Kathryn E. Kenworthy, Stephen E. Clarke, Julie Andrews and J. Brian Houston
Drug Metabolism and Disposition December 2001, 29 (12) 1644-1651;

Article Information

vol. 29 no. 12 1644-1651
PubMed 
11717184
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received May 25, 2001
  • Accepted September 18, 2001
  • Published online December 1, 2001.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Kathryn E. Kenworthy1,1,
  2. Stephen E. Clarke2,
  3. Julie Andrews1 and
  4. J. Brian Houston1
  1. 1School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom (K.E.K., J.A., J.B.H.); and 2Department of Mechanism and Extrapolation Technologies, GlaxoSmithKline, The Frythe, Welwyn, Herts, United Kingdom (S.E.C.)
  1. Dr J. B. Houston, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, M13 9PL, UK. E-mail: brian.houston{at}man.ac.uk
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Research ArticleArticle

Multisite Kinetic Models for CYP3A4: Simultaneous Activation and Inhibition of Diazepam and Testosterone Metabolism

Kathryn E. Kenworthy, Stephen E. Clarke, Julie Andrews and J. Brian Houston
Drug Metabolism and Disposition December 1, 2001, 29 (12) 1644-1651;
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