Table of Contents

Short Communications

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  Pharmacokinetic Studies of 2-Amino-9-(3-acetoxymethyl-4-
  isopropoxycarbonyl-oxybut-1-yl)purine, an Oral Prodrug for the Antiviral Agent Penciclovir

  Won-Son Choi, Guang-Jin Im, Dae-Kee Kim, Tae-Kon Kim, Inho Jung, Taek-Soo Kim, Sung-Jae Lee, Namkyu Lee, Young-Woo Kim, Jae-Sun Kim and Kieyoung Chang

  Drug Metabolism and Disposition July 2001, 29 (7) 945-949;
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  Selective Dehydrogenation/Oxygenation of 3-Methylindole by Cytochrome P450 Enzymes

  Diane L. Lanza and Garold S. Yost

  Drug Metabolism and Disposition July 2001, 29 (7) 950-953;
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  Methadone Inhibits Rhodamine123 Transport in Caco-2 Cells

  Elke Störmer, Michael D. Perloff, Lisa L. von Moltke and David J. Greenblatt

  Drug Metabolism and Disposition July 2001, 29 (7) 954-956;
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  Pharmacokinetic Theory of Cassette Dosing in Drug Discovery Screening

  Ronald E. White and Prasarn Manitpisitkul

  Drug Metabolism and Disposition July 2001, 29 (7) 957-966;
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  Influence of Dose and Infusion Duration on Pharmacokinetics of Ifosfamide and Metabolites

  T. Kerbusch, R. A. A. Mathôt, H. J. Keizer, G. P. Kaijser, J. H. M. Schellens and J. H. Beijnen

  Drug Metabolism and Disposition July 2001, 29 (7) 967-975;
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  Metabolism of Norethisterone and Norethisterone Derivatives in Rat Uterus, Vagina, and Aorta

  M. J. Blom, M. Groot Wassink, F. van Wijk, A. G. H. Ederveen, H. J. Kloosterboer, C. H. J. Verhoeven, J. G. D. Lambert and H. J. Th. Goos

  Drug Metabolism and Disposition July 2001, 29 (7) 976-982;
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  Screening Of Organosulfur Compounds as Inhibitors of Human CYP2A6

  Ken-ichi Fujita and Tetsuya Kamataki

  Drug Metabolism and Disposition July 2001, 29 (7) 983-989;
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  Bexarotene Metabolism in Rat, Dog, and Human, Synthesis of Oxidative Metabolites, and in Vitro Activity at Retinoid Receptors

  Stanley R. Howell, Michael A. Shirley, Timothy A. Grese, David A. Neel, Kirk E. Wells and Edgar H. Ulm

  Drug Metabolism and Disposition July 2001, 29 (7) 990-998;
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  Polycyclic Aromatic Hydrocarbon/Metal Mixtures: Effect on PAH Induction of CYP1A1 in Human HepG2 Cells

  Dilip D. Vakharia, Ning Liu, Ronald Pause, Michael Fasco, Erin Bessette, Qing-Yu Zhang and Laurence S. Kaminsky

  Drug Metabolism and Disposition July 2001, 29 (7) 999-1006;
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  Cytochrome P450 Down-Regulation by Serum from Humans with a Viral Infection and from Rabbits with an Inflammatory Reaction

  Anne-Marie Bleau, Caroline Fradette, Ayman O. S. El-Kadi, Marie-Claude Côté and Patrick du Souich

  Drug Metabolism and Disposition July 2001, 29 (7) 1007-1012;
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  Dietary Uptake Kinetics of 2,2′,5,5′-Tetrachlorobiphenyl in Rainbow Trout

  J. W. Nichols, P. N. Fitzsimmons, F. W. Whiteman, D. W. Kuehl, B. C. Butterworth and C. T. Jenson

  Drug Metabolism and Disposition July 2001, 29 (7) 1013-1022;
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  In Vivo Effect of Clarithromycin on Multiple Cytochrome P450s

  Melissa A. Bruce, Stephen D. Hall, Barbara D. Haehner-Daniels and J. Christopher Gorski

  Drug Metabolism and Disposition July 2001, 29 (7) 1023-1028;
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  Dapsone Activation of CYP2C9-Mediated Metabolism: Evidence for Activation of Multiple Substrates and a Two-Site Model

  J. Matthew Hutzler, Michael J. Hauer and Timothy S. Tracy

  Drug Metabolism and Disposition July 2001, 29 (7) 1029-1034;
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  In Vivo Pharmacokinetics and Metabolism of Anti-Human Immunodeficiency Virus Agent d4T-5′-[p-Bromophenyl Methoxyalaninyl Phosphate] (SAMPIDINE) in Mice

  Chun-Lin Chen, T. K. Venkatachalam, Zhao-Hai Zhu and Fatih M. Uckun

  Drug Metabolism and Disposition July 2001, 29 (7) 1035-1041;
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  Studies Comparing in Vivo:in Vitro Metabolism of Three Pharmaceutical Compounds in Rat, Dog, Monkey, and Human Using Cryopreserved Hepatocytes, Microsomes, and Collagen Gel Immobilized Hepatocyte Cultures

  Nicola J. Hewitt, Karl-Uhlrich Bühring, Johannes Dasenbrock, Jutta Haunschild, Bernhard Ladstetter and Dietmar Utesch

  Drug Metabolism and Disposition July 2001, 29 (7) 1042-1050;
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  Role of CYP2C9 Polymorphism in Losartan Oxidation

  Ümit Yasar, Gunnel Tybring, Mats Hidestrand, Mikael Oscarson, Magnus Ingelman-Sundberg, Marja-Liisa Dahl and Erik Eliasson

  Drug Metabolism and Disposition July 2001, 29 (7) 1051-1056;
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  Cytochrome P450-Catalyzed Metabolism of Ezlopitant Alkene (CJ-12,458), a Pharmacologically Active Metabolite of Ezlopitant: Enzyme Kinetics and Mechanism Of an Alkene Hydration Reaction

  R. Scott Obach

  Drug Metabolism and Disposition July 2001, 29 (7) 1057-1067;
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  Drug Interaction Between Simvastatin and Itraconazole in Male and Female Rats

  Michi Ishigami, Kiyoshi Kawabata, Wataru Takasaki, Toshihiko Ikeda, Toru Komai, Kiyomi Ito and Yuichi Sugiyama

  Drug Metabolism and Disposition July 2001, 29 (7) 1068-1072;