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Articles

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  SPECIES DIFFERENTIAL STEREOSELECTIVE OXIDATION OF A METHYLSULFIDE METABOLITE OF MK-0767 [(±)-5-[(2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[[(4-TRIFLUOROMETHYL)PHENYL]METHYL]BENZAMIDE], A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DUAL AGONIST

  Bindhu V. Karanam, Christopher J. Welch, Vijay G. Reddy, Jennifer Chilenski, Mirlinda Biba and Stella Vincent

  Drug Metabolism and Disposition October 2004, 32 (10) 1061-1068; DOI: https://doi.org/10.1124/dmd.104.000224
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  CONSTRUCTION OF EXPRESSION SYSTEM FOR HUMAN α₁-ACID GLYCOPROTEIN IN PICHIA PASTORIS AND EVALUATION OF ITS DRUG-BINDING PROPERTIES

  Koji Nishi, Naoko Fukunaga and Masaki Otagiri

  Drug Metabolism and Disposition October 2004, 32 (10) 1069-1074; DOI: https://doi.org/10.1124/dmd.104.000513
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  TOCOTRIENOLS ACTIVATE THE STEROID AND XENOBIOTIC RECEPTOR, SXR, AND SELECTIVELY REGULATE EXPRESSION OF ITS TARGET GENES

  Changcheng Zhou, Michelle M. Tabb, Asal Sadatrafiei, Felix Grün and Bruce Blumberg

  Drug Metabolism and Disposition October 2004, 32 (10) 1075-1082; DOI: https://doi.org/10.1124/dmd.104.000299
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  DIFFERENCES IN THE INHIBITION OF CYTOCHROMES P450 3A4 AND 3A5 BY METABOLITE-INHIBITOR COMPLEX-FORMING DRUGS

  Donavon J. McConn, Yvonne S. Lin, Kyle Allen, Kent L. Kunze and Kenneth E. Thummel

  Drug Metabolism and Disposition October 2004, 32 (10) 1083-1091; DOI: https://doi.org/10.1124/dmd.32.10.1083
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  EFFECTIVE DOSING REGIMEN OF 1-AMINOBENZOTRIAZOLE FOR INHIBITION OF ANTIPYRINE CLEARANCE IN GUINEA PIGS AND MICE USING SERIAL SAMPLING

  Suresh K. Balani, Ping Li, Joanne Nguyen, Kym Cardoza, Hang Zeng, Dun-Xue Mu, Jing-Tao Wu, Liang-Shang Gan and Frank W. Lee

  Drug Metabolism and Disposition October 2004, 32 (10) 1092-1095; DOI: https://doi.org/10.1124/dmd.104.000349
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  CHARACTERIZATION OF THE RENAL TUBULAR TRANSPORT OF ZONAMPANEL, A NOVEL α-AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONIC ACID RECEPTOR ANTAGONIST, BY HUMAN ORGANIC ANION TRANSPORTERS

  Tadashi Hashimoto, Shinichi Narikawa, Xiu-Lin Huang, Tsuyoshi Minematsu, Takashi Usui, Hidetaka Kamimura and Hitoshi Endou

  Drug Metabolism and Disposition October 2004, 32 (10) 1096-1102; DOI: https://doi.org/10.1124/dmd.32.10.1096
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  IDENTIFICATION OF THE CYTOSOLIC CARBOXYLESTERASE CATALYZING THE 5′-DEOXY-5-FLUOROCYTIDINE FORMATION FROM CAPECITABINE IN HUMAN LIVER

  Toshiki Tabata, Miki Katoh, Shogo Tokudome, Miki Nakajima and Tsuyoshi Yokoi

  Drug Metabolism and Disposition October 2004, 32 (10) 1103-1110; DOI: https://doi.org/10.1124/dmd.104.000554
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  QUANTITATIVE STRUCTURE-METABOLISM RELATIONSHIP MODELING OF METABOLIC N-DEALKYLATION REACTION RATES

  Konstantin V. Balakin, Sean Ekins, Andrey Bugrim, Yan A. Ivanenkov, Dmitry Korolev, Yuri V. Nikolsky, Andrey A. Ivashchenko, Nikolay P. Savchuk and Tatiana Nikolskaya

  Drug Metabolism and Disposition October 2004, 32 (10) 1111-1120; DOI: https://doi.org/10.1124/dmd.104.000364
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  ROLE OF ITRACONAZOLE METABOLITES IN CYP3A4 INHIBITION

  Nina Isoherranen, Kent L. Kunze, Kyle E. Allen, Wendel L. Nelson and Kenneth E. Thummel

  Drug Metabolism and Disposition October 2004, 32 (10) 1121-1131; DOI: https://doi.org/10.1124/dmd.104.000315
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  PLASMA PHARMACOKINETICS AND METABOLISM OF THE HISTONE DEACETYLASE INHIBITOR TRICHOSTATIN A AFTER INTRAPERITONEAL ADMINISTRATION TO MICE

  L. Sanderson, G. W. Taylor, E. O. Aboagye, J. P. Alao, J. R. Latigo, R. C. Coombes and D. M. Vigushin

  Drug Metabolism and Disposition October 2004, 32 (10) 1132-1138; DOI: https://doi.org/10.1124/dmd.104.000638
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  ESTRADIOL 3-GLUCURONIDE IS TRANSPORTED BY THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2 BUT DOES NOT ACTIVATE THE ALLOSTERIC SITE BOUND BY ESTRADIOL 17-GLUCURONIDE

  Phillip M. Gerk, Wei Li and Mary Vore

  Drug Metabolism and Disposition October 2004, 32 (10) 1139-1145; DOI: https://doi.org/10.1124/dmd.104.000372
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  TWO MAJOR GRAPEFRUIT JUICE COMPONENTS DIFFER IN INTESTINAL CYP3A4 INHIBITION KINETIC AND BINDING PROPERTIES

  Mary F. Paine, Anne B. Criss and Paul B. Watkins

  Drug Metabolism and Disposition October 2004, 32 (10) 1146-1153; DOI: https://doi.org/10.1124/dmd.104.000547
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  IDENTIFICATION AND METABOLISM OF A NOVEL DIHYDROHYDROXY-S-GLUTATHIONYL CONJUGATE OF A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR AGONIST, MK-0767 [(±)-5-[(2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[[(4-TRIFLUOROMETHYL) PHENYL]METHYL]BENZAMIDE], IN RATS

  Vijay Bhasker G. Reddy, George A. Doss, Mellissa Creighton, Christopher J. Kochansky, Stella H. Vincent, Ronald B. Franklin and Bindhu V. Karanam

  Drug Metabolism and Disposition October 2004, 32 (10) 1154-1161; DOI: https://doi.org/10.1124/dmd.104.000240
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  TRICLOSAN AS A SUBSTRATE AND INHIBITOR OF 3′-PHOSPHOADENOSINE 5′-PHOSPHOSULFATE-SULFOTRANSFERASE AND UDP-GLUCURONOSYL TRANSFERASE IN HUMAN LIVER FRACTIONS

  Li-Quan Wang, Charles N. Falany and Margaret O. James

  Drug Metabolism and Disposition October 2004, 32 (10) 1162-1169; DOI: https://doi.org/10.1124/dmd.104.000273
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  IDENTIFICATION OF DI-(2-ETHYLHEXYL) PHTHALATE-INDUCED CARBOXYLESTERASE 1 IN C57BL/6 MOUSE LIVER MICROSOMES: PURIFICATION, CDNA CLONING, AND BACULOVIRUS-MEDIATED EXPRESSION

  Tomomi Furihata, Masakiyo Hosokawa, Nao Koyano, Takahiro Nakamura, Tetsuo Satoh and Kan Chiba

  Drug Metabolism and Disposition October 2004, 32 (10) 1170-1177; DOI: https://doi.org/10.1124/dmd.104.000620
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  A CRUCIAL ROLE OF URIDINE/CYTIDINE KINASE 2 IN ANTITUMOR ACTIVITY OF 3′-ETHYNYL NUCLEOSIDES

  Daigo Murata, Yoshio Endo, Tohru Obata, Kazuki Sakamoto, Yasuhiro Syouji, Masakazu Kadohira, Akira Matsuda and Takuma Sasaki

  Drug Metabolism and Disposition October 2004, 32 (10) 1178-1182; DOI: https://doi.org/10.1124/dmd.104.000737
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  KOHONEN MAPS FOR PREDICTION OF BINDING TO HUMAN CYTOCHROME P450 3A4

  Konstantin V. Balakin, Sean Ekins, Andrey Bugrim, Yan A. Ivanenkov, Dmitry Korolev, Yuri V. Nikolsky, Andrey V. Skorenko, Andrey A. Ivashchenko, Nikolay P. Savchuk and Tatiana Nikolskaya

  Drug Metabolism and Disposition October 2004, 32 (10) 1183-1189; DOI: https://doi.org/10.1124/dmd.104.000356
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  UTILITY OF WHOLE-BODY AUTORADIOLUMINOGRAPHY IN DRUG DISCOVERY FOR THE QUANTIFICATION OF TRITIUM-LABELED DRUG CANDIDATES

  Michael J. Potchoiba and Mark R. Nocerini

  Drug Metabolism and Disposition October 2004, 32 (10) 1190-1198; DOI: https://doi.org/10.1124/dmd.32.10.1190