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Inoculation of Human Tumor Cells Alters the Basal Expression but Not the Inducibility of Cytochrome P450 Enzymes in Tumor-Bearing Mouse Liver

Michiko Sugawara, Kiyoshi Okamoto, Tadashi Kadowaki, Kazutomi Kusano, Akiyoshi Fukamizu and Tsutomu Yoshimura
Drug Metabolism and Disposition November 2009, 37 (11) 2244-2254; DOI: https://doi.org/10.1124/dmd.109.028571

Article Information

vol. 37 no. 11 2244-2254
DOI 
https://doi.org/10.1124/dmd.109.028571
PubMed 
19666990
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 2, 2009
  • Accepted August 6, 2009
  • Published online October 16, 2009.

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Copyright & Usage 
Copyright © 2009 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Michiko Sugawara,
  2. Kiyoshi Okamoto,
  3. Tadashi Kadowaki,
  4. Kazutomi Kusano,
  5. Akiyoshi Fukamizu and
  6. Tsutomu Yoshimura
  1. Drug Metabolism and Pharmacokinetics Research (M.S., K.K., T.Y.), Discovery Research Laboratories II (K.O.), and Core Technology Research (T.K.), Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Japan; and Center for Tsukuba Advanced Research Alliance and Graduate School of Life and Environmental Sciences, Tsukuba University, Tsukuba, Japan (A.F.)
  1. Address correspondence to:
    Dr. Michiko Sugawara,Drug Metabolism and Pharmacokinetics Research, Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan. E-mail: m-sugawara{at}hhc.eisai.co.jp
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Inoculation of Human Tumor Cells Alters the Basal Expression but Not the Inducibility of Cytochrome P450 Enzymes in Tumor-Bearing Mouse Liver

Michiko Sugawara, Kiyoshi Okamoto, Tadashi Kadowaki, Kazutomi Kusano, Akiyoshi Fukamizu and Tsutomu Yoshimura
Drug Metabolism and Disposition November 1, 2009, 37 (11) 2244-2254; DOI: https://doi.org/10.1124/dmd.109.028571
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