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Research ArticleArticle

Mild Hypothermia Alters Midazolam Pharmacokinetics in Normal Healthy Volunteers

David Hostler, Jiangquan Zhou, Michael A. Tortorici, Robert R. Bies, Jon C. Rittenberger, Philip E. Empey, Patrick M. Kochanek, Clifton W. Callaway and Samuel M. Poloyac
Drug Metabolism and Disposition May 2010, 38 (5) 781-788; DOI: https://doi.org/10.1124/dmd.109.031377

Article Information

vol. 38 no. 5 781-788
DOI 
https://doi.org/10.1124/dmd.109.031377
PubMed 
20164112
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 25, 2009
  • Accepted February 17, 2010
  • Published online April 15, 2010.

Article Versions

Copyright & Usage 
Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. David Hostler,
  2. Jiangquan Zhou,
  3. Michael A. Tortorici,
  4. Robert R. Bies,
  5. Jon C. Rittenberger,
  6. Philip E. Empey,
  7. Patrick M. Kochanek,
  8. Clifton W. Callaway and
  9. Samuel M. Poloyac
  1. Department of Emergency Medicine, Emergency Responder Human Performance Laboratory (D.H., J.C.R., C.W.C.), Department of Pharmaceutical Sciences, School of Pharmacy (J.Z., M.A.T., R.R.B., P.E.E., S.M.P.), and Department of Critical Care Medicine, Safar Center for Resuscitation Research (P.M.K.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  1. Address correspondence to:
    Dr. Samuel M. Poloyac, 807 Salk Hall, Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261. E-mail: poloyac{at}pitt.edu

  1. D.H. and J.Z. contributed equally to this work.

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Research ArticleArticle

Mild Hypothermia Alters Midazolam Pharmacokinetics in Normal Healthy Volunteers

David Hostler, Jiangquan Zhou, Michael A. Tortorici, Robert R. Bies, Jon C. Rittenberger, Philip E. Empey, Patrick M. Kochanek, Clifton W. Callaway and Samuel M. Poloyac
Drug Metabolism and Disposition May 1, 2010, 38 (5) 781-788; DOI: https://doi.org/10.1124/dmd.109.031377
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