Table of Contents

Articles

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  Activation of Cyclosporin A Transport by a Novel λ Light Chain of Human Ig Surface Antigen-Related Gene in Xenopus laevis Oocytes

  Yasuna Kobayashi, Takahiro Umemoto, Masayuki Ohbayashi, Noriko Kohyama, Yutaka Sanada and Toshinori Yamamoto

  Drug Metabolism and Disposition September 2010, 38 (9) 1427-1435; DOI: https://doi.org/10.1124/dmd.109.030916
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  Pharmacokinetic-Pharmacodynamic Modeling of Tumor Growth Inhibition and Biomarker Modulation by the Novel Phosphatidylinositol 3-Kinase Inhibitor GDC-0941

  Laurent Salphati, Harvey Wong, Marcia Belvin, Delia Bradford, Kyle A. Edgar, Wei Wei Prior, Deepak Sampath and Jeffrey J. Wallin

  Drug Metabolism and Disposition September 2010, 38 (9) 1436-1442; DOI: https://doi.org/10.1124/dmd.110.032912
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  The Dipeptidyl Peptidase-4 Inhibitor Linagliptin Exhibits Time- and Dose-Dependent Localization in Kidney, Liver, and Intestine after Intravenous Dosing: Results from High Resolution Autoradiography in Rats

  Andreas Greischel, Rudolf Binder and Juergen Baierl

  Drug Metabolism and Disposition September 2010, 38 (9) 1443-1448; DOI: https://doi.org/10.1124/dmd.110.034199
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  Metabolite Formation Kinetics and Intrinsic Clearance of Phenacetin, Tolbutamide, Alprazolam, and Midazolam in Adenoviral Cytochrome P450-Transfected HepG2 Cells and Comparison with Hepatocytes and In Vivo

  M. Teresa Donato, David Hallifax, Laura Picazo, José V. Castell, J. Brian Houston, M. José Gomez-Lechón and Agustin Lahoz

  Drug Metabolism and Disposition September 2010, 38 (9) 1449-1455; DOI: https://doi.org/10.1124/dmd.110.033605
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  Effect of the CYP2D6*10 Genotype on Tolterodine Pharmacokinetics

  Masayo Oishi, Koji Chiba, Bimal Malhotra and Toshio Suwa

  Drug Metabolism and Disposition September 2010, 38 (9) 1456-1463; DOI: https://doi.org/10.1124/dmd.110.033407
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  Metabolism of Tanshinol Borneol Ester in Rat and Human Liver Microsomes

  Duan Liu, Xiaohui Zheng, Yitong Tang, Jing Zi, Yefei Nan, Shixiang Wang, Chaoni Xiao, Juanli Zhu and Chao Chen

  Drug Metabolism and Disposition September 2010, 38 (9) 1464-1470; DOI: https://doi.org/10.1124/dmd.110.033381
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  In Vitro Metabolism, Permeability, and Efflux of Bazedoxifene in Humans

  Li Shen, Syed Ahmad, SeongHee Park, William DeMaio, Aram Oganesian, Theresa Hultin, JoAnn Scatina, Peter Bungay and Appavu Chandrasekaran

  Drug Metabolism and Disposition September 2010, 38 (9) 1471-1479; DOI: https://doi.org/10.1124/dmd.109.030999
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  Discontinuous Drug Binding to Proteins: Binding of an Antineoplastic Benzyl Styryl Sulfone to Albumin and Enzymes In Vitro and in Phase I Clinical Trials

  Sool Yeon Cho, Takao Ohnuma, Lewis R. Silverman, James F. Holland and John Roboz

  Drug Metabolism and Disposition September 2010, 38 (9) 1480-1485; DOI: https://doi.org/10.1124/dmd.110.033001
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  Cynomolgus Monkey CYP2D44 Newly Identified in Liver, Metabolizes Bufuralol, and Dextromethorphan

  Yasuhiro Uno, Shotaro Uehara, Sakae Kohara, Norie Murayama and Hiroshi Yamazaki

  Drug Metabolism and Disposition September 2010, 38 (9) 1486-1492; DOI: https://doi.org/10.1124/dmd.110.033274
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  Histone Deacetylase Inhibitors Induce Cytochrome P450 2B by Activating Nuclear Receptor Constitutive Androstane Receptor

  Daichi Takizawa, Satoru Kakizaki, Norio Horiguchi, Hiroki Tojima, Yuichi Yamazaki, Takeshi Ichikawa, Ken Sato and Masatomo Mori

  Drug Metabolism and Disposition September 2010, 38 (9) 1493-1498; DOI: https://doi.org/10.1124/dmd.110.032854
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  Cyclosporine A, but Not Tacrolimus, Shows Relevant Inhibition of Organic Anion-Transporting Protein 1B1-Mediated Transport of Atorvastatin

  Rune Amundsen, Hege Christensen, Behnaz Zabihyan and Anders Åsberg

  Drug Metabolism and Disposition September 2010, 38 (9) 1499-1504; DOI: https://doi.org/10.1124/dmd.110.032268
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  Estimation of Transporters Involved in the Hepatobiliary Transport of TA-0201CA Using Sandwich-Cultured Rat Hepatocytes from Normal and Multidrug Resistance-Associated Protein 2-Deficient Rats

  Hajime Fukuda, Rikiya Ohashi, Noriko Ohashi, Hikaru Yabuuchi and Ikumi Tamai

  Drug Metabolism and Disposition September 2010, 38 (9) 1505-1513; DOI: https://doi.org/10.1124/dmd.110.033258
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  Absorption, Distribution, Metabolism, and Excretion of Ticagrelor in Healthy Subjects

  Renli Teng, Stuart Oliver, Martin A. Hayes and Kathleen Butler

  Drug Metabolism and Disposition September 2010, 38 (9) 1514-1521; DOI: https://doi.org/10.1124/dmd.110.032250
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  Novel Metabolic Bioactivation Mechanism for a Series of Anti-Inflammatory Agents (2,5-Diaminothiophene Derivatives) Mediated by Cytochrome P450 Enzymes

  Yiding Hu, Shengtian Yang, F. Barclay Shilliday, Bruce R. Heyde, Kathy M. Mandrell, Russell H. Robins, Jin Xie, Matthew T. Reding, Yurong Lai and David C. Thompson

  Drug Metabolism and Disposition September 2010, 38 (9) 1522-1531; DOI: https://doi.org/10.1124/dmd.110.032581
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  Arylacetamide Deacetylase Is a Determinant Enzyme for the Difference in Hydrolase Activities of Phenacetin and Acetaminophen

  Akinobu Watanabe, Tatsuki Fukami, Shiori Takahashi, Yuki Kobayashi, Nao Nakagawa, Miki Nakajima and Tsuyoshi Yokoi

  Drug Metabolism and Disposition September 2010, 38 (9) 1532-1537; DOI: https://doi.org/10.1124/dmd.110.033720
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  Identification of Valproic Acid Glucuronide Hydrolase As a Key Enzyme for the Interaction of Valproic Acid with Carbapenem Antibiotics

  Eiko Suzuki, Naotoshi Yamamura, Yuji Ogura, Daisuke Nakai, Kazuishi Kubota, Nobuhiro Kobayashi, Shin-ichi Miura and Osamu Okazaki

  Drug Metabolism and Disposition September 2010, 38 (9) 1538-1544; DOI: https://doi.org/10.1124/dmd.110.032938
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  Methemoglobinemia Induced by 1,2-Dichloro-4-nitrobenzene in Mice with a Disrupted Glutathione S-Transferase Mu 1 Gene

  Shingo Arakawa, Takanori Maejima, Naoki Kiyosawa, Takashi Yamaguchi, Yukari Shibaya, Yoshie Aida, Ryota Kawai, Kazunori Fujimoto, Sunao Manabe and Wataru Takasaki

  Drug Metabolism and Disposition September 2010, 38 (9) 1545-1552; DOI: https://doi.org/10.1124/dmd.110.033597
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  Purified Mouse CYP27B1 Can Hydroxylate 20,23-Dihydroxyvitamin D₃, Producing 1α,20,23-Trihydroxyvitamin D₃, Which Has Altered Biological Activity

  Edith K. Y. Tang, Wei Li, Zorica Janjetovic, Minh N. Nguyen, Zhao Wang, Andrzej Slominski and Robert C. Tuckey

  Drug Metabolism and Disposition September 2010, 38 (9) 1553-1559; DOI: https://doi.org/10.1124/dmd.110.034389
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  Role of P-Glycoprotein in Region-Specific Gastrointestinal Absorption of Talinolol in Rats

  Leonid Kagan, Tali Dreifinger, Donald E. Mager and Amnon Hoffman

  Drug Metabolism and Disposition September 2010, 38 (9) 1560-1566; DOI: https://doi.org/10.1124/dmd.110.033019
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  Dabigatran Acylglucuronide, the Major Human Metabolite of Dabigatran: In Vitro Formation, Stability, and Pharmacological Activity

  Thomas Ebner, Klaus Wagner and Wolfgang Wienen

  Drug Metabolism and Disposition September 2010, 38 (9) 1567-1575; DOI: https://doi.org/10.1124/dmd.110.033696
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  Proton-Coupled Erythromycin Antiport at Rat Blood-Placenta Barrier

  Yoshimichi Sai, Tomohiro Nishimura, Kaori Ochi, Noriaki Tanaka, Akinori Takagi, Masatoshi Tomi, Noriko Kose, Yasuna Kobayashi, Naoki Miyakoshi, Shinji Kitagaki, Chisato Mukai and Emi Nakashima

  Drug Metabolism and Disposition September 2010, 38 (9) 1576-1581; DOI: https://doi.org/10.1124/dmd.110.033266
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  Constitutive Androgen Receptor-Null Mice Are Sensitive to the Toxic Effects of Parathion: Association with Reduced Cytochrome P450-Mediated Parathion Metabolism

  Linda C. Mota, Juan P. Hernandez and William S. Baldwin

  Drug Metabolism and Disposition September 2010, 38 (9) 1582-1588; DOI: https://doi.org/10.1124/dmd.110.032961
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  Profiling Induction of Cytochrome P450 Enzyme Activity by Statins Using a New Liquid Chromatography-Tandem Mass Spectrometry Cocktail Assay in Human Hepatocytes

  Diana M. Feidt, Kathrin Klein, Ute Hofmann, Stephan Riedmaier, Daniel Knobeloch, Wolfgang E. Thasler, Thomas S. Weiss, Matthias Schwab and Ulrich M. Zanger

  Drug Metabolism and Disposition September 2010, 38 (9) 1589-1597; DOI: https://doi.org/10.1124/dmd.110.033886
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  Liverbeads: A Practical and Relevant In Vitro Model for Gene Induction Investigations

  Ihab Al Khansa, Olivier Blanck, André Guillouzo and Rémi Bars

  Drug Metabolism and Disposition September 2010, 38 (9) 1598-1604; DOI: https://doi.org/10.1124/dmd.110.033753
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  Cytochrome P450 3A4 mRNA Is a More Reliable Marker than CYP3A4 Activity for Detecting Pregnane X Receptor-Activated Induction of Drug-Metabolizing Enzymes

  Odette A. Fahmi, Mary Kish, Sherri Boldt and R. Scott Obach

  Drug Metabolism and Disposition September 2010, 38 (9) 1605-1611; DOI: https://doi.org/10.1124/dmd.110.033126
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  Inhibition of Hepatic Organic Anion-Transporting Polypeptide by RNA Interference in Sandwich-Cultured Human Hepatocytes: An In Vitro Model to Assess Transporter-Mediated Drug-Drug Interactions

  Mingxiang Liao, Arek R. Raczynski, Michael Chen, Bei-Ching Chuang, Qing Zhu, Rob Shipman, Jodi Morrison, David Lee, Frank W. Lee, Suresh K. Balani and Cindy Q. Xia

  Drug Metabolism and Disposition September 2010, 38 (9) 1612-1622; DOI: https://doi.org/10.1124/dmd.110.032995