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Research ArticleArticle

Characterization of the Expression and Activity of Carboxylesterases 1 and 2 from the Beagle Dog, Cynomolgus Monkey, and Human

Eric T. Williams, James A. Bacon, David M. Bender, Jennifer J. Lowinger, Wen-Kai Guo, Mariam E. Ehsani, Xiliang Wang, He Wang, Yue-Wei Qian, Kenneth J. Ruterbories, Steven A. Wrighton and Everett J. Perkins
Drug Metabolism and Disposition December 2011, 39 (12) 2305-2313; DOI: https://doi.org/10.1124/dmd.111.041335

Article Information

vol. 39 no. 12 2305-2313
DOI 
https://doi.org/10.1124/dmd.111.041335
PubMed 
21918037
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 1, 2011
  • Accepted September 14, 2011
  • Published online November 21, 2011.

Article Versions

Copyright & Usage 
Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Eric T. Williams1,
  2. James A. Bacon,
  3. David M. Bender,
  4. Jennifer J. Lowinger2,
  5. Wen-Kai Guo,
  6. Mariam E. Ehsani,
  7. Xiliang Wang,
  8. He Wang,
  9. Yue-Wei Qian,
  10. Kenneth J. Ruterbories,
  11. Steven A. Wrighton and
  12. Everett J. Perkins
  1. Departments of Drug Disposition (E.T.W., J.A.B., J.J.L., W.-K.G., K.J.R., S.A.W., E.J.P.), Chemistry (D.M.B.), and Integrative Biology (M.E.E., X.W., H.W., Y.-W.Q.), Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana
  1. Address correspondence to:
    Dr. Everett J. Perkins, Eli Lilly and Company, Lilly Research Laboratories, Drop Code 0710, Indianapolis, IN 46285. E-mail: perkins_everett_j{at}lilly.com

  • ↵1 Current affiliation: Eisai Inc., Andover, Massachusetts.

  • ↵2 Current affiliation: Bristol-Myers Squibb, Pennington, New Jersey.

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CROSS-SPECIES CHARACTERIZATION OF CARBOXYLESTERASES

Eric T. Williams, James A. Bacon, David M. Bender, Jennifer J. Lowinger, Wen-Kai Guo, Mariam E. Ehsani, Xiliang Wang, He Wang, Yue-Wei Qian, Kenneth J. Ruterbories, Steven A. Wrighton and Everett J. Perkins
Drug Metabolism and Disposition December 1, 2011, 39 (12) 2305-2313; DOI: https://doi.org/10.1124/dmd.111.041335
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