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Research ArticleArticle

Repeated Injection of High Doses of Hemoglobin-Encapsulated Liposomes (Hemoglobin Vesicles) Induces Accelerated Blood Clearance in a Hemorrhagic Shock Rat Model

Kazuaki Taguchi, Yasunori Iwao, Hiroshi Watanabe, Daisuke Kadowaki, Hiromi Sakai, Koichi Kobayashi, Hirohisa Horinouchi, Toru Maruyama and Masaki Otagiri
Drug Metabolism and Disposition March 2011, 39 (3) 484-489; DOI: https://doi.org/10.1124/dmd.110.036913

Article Information

vol. 39 no. 3 484-489
DOI 
https://doi.org/10.1124/dmd.110.036913
PubMed 
21123166
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 24, 2010
  • Accepted December 1, 2010
  • Published online February 17, 2011.

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Copyright & Usage 
Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Kazuaki Taguchi,
  2. Yasunori Iwao,
  3. Hiroshi Watanabe,
  4. Daisuke Kadowaki,
  5. Hiromi Sakai,
  6. Koichi Kobayashi,
  7. Hirohisa Horinouchi,
  8. Toru Maruyama and
  9. Masaki Otagiri
  1. Department of Biopharmaceutics (K.T., Y.I., H.W., D.K., T.M., M.O.), Center for Clinical Pharmaceutical Sciences (H.W., D.K., T.M.), Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan; Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan (M.O.); Research Institute for Science and Engineering, Waseda University, Tokyo, Japan (H.S.); and Department of Surgery, School of Medicine, Keio University, Tokyo, Japan (K.K., H.H.)
  1. Address correspondence to:
    Dr. Masaki Otagiri, Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan. E-mail: otagirim{at}gpo.kumamoto-u.ac.jp
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Research ArticleArticle

Repeated Injection of High Doses of Hemoglobin-Encapsulated Liposomes (Hemoglobin Vesicles) Induces Accelerated Blood Clearance in a Hemorrhagic Shock Rat Model

Kazuaki Taguchi, Yasunori Iwao, Hiroshi Watanabe, Daisuke Kadowaki, Hiromi Sakai, Koichi Kobayashi, Hirohisa Horinouchi, Toru Maruyama and Masaki Otagiri
Drug Metabolism and Disposition March 1, 2011, 39 (3) 484-489; DOI: https://doi.org/10.1124/dmd.110.036913
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