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In Vitro Evaluation of Hepatic Transporter-Mediated Clinical Drug-Drug Interactions: Hepatocyte Model Optimization and Retrospective Investigation

Yi-an Bi, Emi Kimoto, Samantha Sevidal, Hannah M. Jones, Hugh A. Barton, Sarah Kempshall, Kevin M. Whalen, Hui Zhang, Chengjie Ji, Katherine S. Fenner, Ayman F. El-Kattan and Yurong Lai
Drug Metabolism and Disposition June 2012, 40 (6) 1085-1092; DOI: https://doi.org/10.1124/dmd.111.043489

Article Information

vol. 40 no. 6 1085-1092
DOI 
https://doi.org/10.1124/dmd.111.043489
PubMed 
22381335
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 28, 2011
  • Accepted March 1, 2012
  • Published online May 16, 2012.

Article Versions

Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yi-an Bi,
  2. Emi Kimoto,
  3. Samantha Sevidal,
  4. Hannah M. Jones,
  5. Hugh A. Barton,
  6. Sarah Kempshall,
  7. Kevin M. Whalen,
  8. Hui Zhang,
  9. Chengjie Ji,
  10. Katherine S. Fenner,
  11. Ayman F. El-Kattan and
  12. Yurong Lai
  1. Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut (Y.B., E.K., H.A.B., K.M.W., H.Z., C.J., A.F.E., Y.L.); La Jolla Laboratories, La Jolla, California (S.S.); and Sandwich Laboratories, Kent, United Kingdom (H.M.J., S.K., K.S.F.)
  1. Address correspondence to:
    Dr. Yurong Lai, Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Pfizer, Inc., Mailstop 8220-2475, Groton, CT 06340. E-mail: yurong.lai{at}pfizer.com

  1. Y.B. and E.K. contributed equally to this work.

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IN VITRO EVALUATION OF OATP-MEDIATED DDI

Yi-an Bi, Emi Kimoto, Samantha Sevidal, Hannah M. Jones, Hugh A. Barton, Sarah Kempshall, Kevin M. Whalen, Hui Zhang, Chengjie Ji, Katherine S. Fenner, Ayman F. El-Kattan and Yurong Lai
Drug Metabolism and Disposition June 1, 2012, 40 (6) 1085-1092; DOI: https://doi.org/10.1124/dmd.111.043489
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