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Research ArticleArticle

Species Difference in the Mechanism of Nonlinear Pharmacokinetics of E2074, a Novel Sodium Channel Inhibitor, in Rats, Dogs, and Monkeys

Yoko Nagaya, Osamu Takenaka, Kazutomi Kusano and Tsutomu Yoshimura
Drug Metabolism and Disposition May 2013, 41 (5) 1004-1011; DOI: https://doi.org/10.1124/dmd.112.050062

Article Information

vol. 41 no. 5 1004-1011
DOI 
https://doi.org/10.1124/dmd.112.050062
PubMed 
23401471
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 15, 2012
  • Accepted February 11, 2013
  • Published online April 15, 2013.

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Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yoko Nagaya,
  2. Osamu Takenaka,
  3. Kazutomi Kusano, and
  4. Tsutomu Yoshimura
  1. Global Drug Metabolism and Pharmacokinetics, Eisai Product Creation Systems, Eisai Co., Ltd., Ibaraki, Japan
  1. Address correspondence to:
    Yoko Nagaya, Drug Metabolism and Pharmacokinetics Japan, Eisai Product Creation Systems, Eisai Co., Ltd., 1-3, Tokodai 5-Chome Tsukuba-shi, Ibaraki 300-2635, Japan. E-mail: y-nagaya{at}hhc.eisai.co.jp
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Research ArticleArticle

Species Difference of Nonlinear Pharmacokinetics of E2074

Yoko Nagaya, Osamu Takenaka, Kazutomi Kusano and Tsutomu Yoshimura
Drug Metabolism and Disposition May 1, 2013, 41 (5) 1004-1011; DOI: https://doi.org/10.1124/dmd.112.050062
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