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Research ArticleArticle

Mechanism-Based Inactivation of Human Cytochrome P450 3A4 by Two Piperazine-Containing Compounds

Amanda K. Bolles, Rina Fujiwara, Erran D. Briggs, Amin A. Nomeir and Laura Lowe Furge
Drug Metabolism and Disposition December 2014, 42 (12) 2087-2096; DOI: https://doi.org/10.1124/dmd.114.060459

Article Information

vol. 42 no. 12 2087-2096
DOI 
https://doi.org/10.1124/dmd.114.060459
PubMed 
25273356
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 26, 2014
  • Accepted October 1, 2014
  • Published online October 31, 2014.

Article Versions

Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Amanda K. Bolles,
  2. Rina Fujiwara,
  3. Erran D. Briggs,
  4. Amin A. Nomeir, and
  5. Laura Lowe Furge
  1. Amin Nomeir Pharmaceutical Consulting, LLC, Milford, New Jersey (A.A.N.); and Department of Chemistry, Kalamazoo College, Kalamazoo, Michigan (A.K.B., R.F., E.D.B., L.L.F.)
  1. Address correspondence to:
    Laura Lowe Furge, Department of Chemistry, Kalamazoo College, 1200 Academy Street, Kalamazoo, MI 49006. E-mail: laura.furge{at}kzoo.edu.
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Inactivation of CYP3A4 by SCH 66712 and EMTPP

Amanda K. Bolles, Rina Fujiwara, Erran D. Briggs, Amin A. Nomeir and Laura Lowe Furge
Drug Metabolism and Disposition December 1, 2014, 42 (12) 2087-2096; DOI: https://doi.org/10.1124/dmd.114.060459
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