Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.M.F., M.L., E.P., C.B., P.D.G., B.W., L.C., Y.D.) and Ware, United Kingdom (C.F.); Department of Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline, King of Prussia, Pennsylvania (J.Z.); Department of Projects Clinical Pharmacology and Sciences, GlaxoSmithKline, Research Triangle Park, North Carolina (L.J., P.S., O.N., P.P.) and Collegeville, Pennsylvania (E.D.)

Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.M.F., M.L., E.P., C.B., P.D.G., B.W., L.C., Y.D.) and Ware, United Kingdom (C.F.); Department of Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline, King of Prussia, Pennsylvania (J.Z.); Department of Projects Clinical Pharmacology and Sciences, GlaxoSmithKline, Research Triangle Park, North Carolina (L.J., P.S., O.N., P.P.) and Collegeville, Pennsylvania (E.D.)

Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.M.F., M.L., E.P., C.B., P.D.G., B.W., L.C., Y.D.) and Ware, United Kingdom (C.F.); Department of Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline, King of Prussia, Pennsylvania (J.Z.); Department of Projects Clinical Pharmacology and Sciences, GlaxoSmithKline, Research Triangle Park, North Carolina (L.J., P.S., O.N., P.P.) and Collegeville, Pennsylvania (E.D.)

Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.M.F., M.L., E.P., C.B., P.D.G., B.W., L.C., Y.D.) and Ware, United Kingdom (C.F.); Department of Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline, King of Prussia, Pennsylvania (J.Z.); Department of Projects Clinical Pharmacology and Sciences, GlaxoSmithKline, Research Triangle Park, North Carolina (L.J., P.S., O.N., P.P.) and Collegeville, Pennsylvania (E.D.)

Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.M.F., M.L., E.P., C.B., P.D.G., B.W., L.C., Y.D.) and Ware, United Kingdom (C.F.); Department of Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline, King of Prussia, Pennsylvania (J.Z.); Department of Projects Clinical Pharmacology and Sciences, GlaxoSmithKline, Research Triangle Park, North Carolina (L.J., P.S., O.N., P.P.) and Collegeville, Pennsylvania (E.D.)

Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.M.F., M.L., E.P., C.B., P.D.G., B.W., L.C., Y.D.) and Ware, United Kingdom (C.F.); Department of Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline, King of Prussia, Pennsylvania (J.Z.); Department of Projects Clinical Pharmacology and Sciences, GlaxoSmithKline, Research Triangle Park, North Carolina (L.J., P.S., O.N., P.P.) and Collegeville, Pennsylvania (E.D.)

Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.M.F., M.L., E.P., C.B., P.D.G., B.W., L.C., Y.D.) and Ware, United Kingdom (C.F.); Department of Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline, King of Prussia, Pennsylvania (J.Z.); Department of Projects Clinical Pharmacology and Sciences, GlaxoSmithKline, Research Triangle Park, North Carolina (L.J., P.S., O.N., P.P.) and Collegeville, Pennsylvania (E.D.)

Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.M.F., M.L., E.P., C.B., P.D.G., B.W., L.C., Y.D.) and Ware, United Kingdom (C.F.); Department of Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline, King of Prussia, Pennsylvania (J.Z.); Department of Projects Clinical Pharmacology and Sciences, GlaxoSmithKline, Research Triangle Park, North Carolina (L.J., P.S., O.N., P.P.) and Collegeville, Pennsylvania (E.D.)

Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.M.F., M.L., E.P., C.B., P.D.G., B.W., L.C., Y.D.) and Ware, United Kingdom (C.F.); Department of Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline, King of Prussia, Pennsylvania (J.Z.); Department of Projects Clinical Pharmacology and Sciences, GlaxoSmithKline, Research Triangle Park, North Carolina (L.J., P.S., O.N., P.P.) and Collegeville, Pennsylvania (E.D.)

Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.M.F., M.L., E.P., C.B., P.D.G., B.W., L.C., Y.D.) and Ware, United Kingdom (C.F.); Department of Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline, King of Prussia, Pennsylvania (J.Z.); Department of Projects Clinical Pharmacology and Sciences, GlaxoSmithKline, Research Triangle Park, North Carolina (L.J., P.S., O.N., P.P.) and Collegeville, Pennsylvania (E.D.)

Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.M.F., M.L., E.P., C.B., P.D.G., B.W., L.C., Y.D.) and Ware, United Kingdom (C.F.); Department of Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline, King of Prussia, Pennsylvania (J.Z.); Department of Projects Clinical Pharmacology and Sciences, GlaxoSmithKline, Research Triangle Park, North Carolina (L.J., P.S., O.N., P.P.) and Collegeville, Pennsylvania (E.D.)

Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.M.F., M.L., E.P., C.B., P.D.G., B.W., L.C., Y.D.) and Ware, United Kingdom (C.F.); Department of Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline, King of Prussia, Pennsylvania (J.Z.); Department of Projects Clinical Pharmacology and Sciences, GlaxoSmithKline, Research Triangle Park, North Carolina (L.J., P.S., O.N., P.P.) and Collegeville, Pennsylvania (E.D.)

Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.M.F., M.L., E.P., C.B., P.D.G., B.W., L.C., Y.D.) and Ware, United Kingdom (C.F.); Department of Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline, King of Prussia, Pennsylvania (J.Z.); Department of Projects Clinical Pharmacology and Sciences, GlaxoSmithKline, Research Triangle Park, North Carolina (L.J., P.S., O.N., P.P.) and Collegeville, Pennsylvania (E.D.)

Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.M.F., M.L., E.P., C.B., P.D.G., B.W., L.C., Y.D.) and Ware, United Kingdom (C.F.); Department of Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline, King of Prussia, Pennsylvania (J.Z.); Department of Projects Clinical Pharmacology and Sciences, GlaxoSmithKline, Research Triangle Park, North Carolina (L.J., P.S., O.N., P.P.) and Collegeville, Pennsylvania (E.D.)

Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, King of Prussia, Pennsylvania (D.M.F., M.L., E.P., C.B., P.D.G., B.W., L.C., Y.D.) and Ware, United Kingdom (C.F.); Department of Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline, King of Prussia, Pennsylvania (J.Z.); Department of Projects Clinical Pharmacology and Sciences, GlaxoSmithKline, Research Triangle Park, North Carolina (L.J., P.S., O.N., P.P.) and Collegeville, Pennsylvania (E.D.)