Research ArticleCommentary
When Is It Important to Measure Unbound Drug in Evaluating Nanomedicine Pharmacokinetics?
Stephan T. Stern, Marilyn N. Martinez and David M. Stevens
Drug Metabolism and Disposition December 2016, 44 (12) 1934-1939; DOI: https://doi.org/10.1124/dmd.116.073148
Stephan T. Stern
Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland (S.T.S., D.M.S.); and Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, Rockville, Maryland (M.N.M.)
Marilyn N. Martinez
Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland (S.T.S., D.M.S.); and Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, Rockville, Maryland (M.N.M.)
David M. Stevens
Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland (S.T.S., D.M.S.); and Food and Drug Administration, Center for Veterinary Medicine, Office of New Animal Drug Evaluation, Rockville, Maryland (M.N.M.)
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In this issue
Research ArticleCommentary
When Is Unbound Drug Important in Evaluating Nanomedicine PK?
Stephan T. Stern, Marilyn N. Martinez and David M. Stevens
Drug Metabolism and Disposition December 1, 2016, 44 (12) 1934-1939; DOI: https://doi.org/10.1124/dmd.116.073148
Jump to section
- Article
- Abstract
- Introduction
- Traditional Protein-Binding PK Paradigms
- Nanoparticle PK
- Equilibrium Formulations
- Redefining Biologically Active Drug Fraction and Its Impact on the PK/PD of Nanoformulations
- Debating the Question: When Unbound Fractions May Need to be Considered
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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