Research ArticleCommentary
Clearance Prediction Methodology Needs Fundamental Improvement: Trends Common to Rat and Human Hepatocytes/Microsomes and Implications for Experimental Methodology
F. L. Wood, J. B. Houston and D. Hallifax
Drug Metabolism and Disposition November 2017, 45 (11) 1178-1188; DOI: https://doi.org/10.1124/dmd.117.077040
F. L. Wood
Centre for Applied Pharmacokinetic Research, Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
J. B. Houston
Centre for Applied Pharmacokinetic Research, Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
D. Hallifax
Centre for Applied Pharmacokinetic Research, Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
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Research ArticleCommentary
In Vitro Assay Performance for Prediction of Clearance
F. L. Wood, J. B. Houston and D. Hallifax
Drug Metabolism and Disposition November 1, 2017, 45 (11) 1178-1188; DOI: https://doi.org/10.1124/dmd.117.077040
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- Article
- Abstract
- Introduction
- Data Collation and Analysis
- Comparison of Human and Rat In Vitro Prediction of Intrinsic Clearance
- Comparison of Predictions from Fresh and Cryopreserved Human Hepatocytes
- Relationship between Empirical Scaling Factor and In Vivo Clearance
- Prediction of In Vivo Clearance of UGT Substrates
- Prediction of In Vivo Clearance of Acidic, Basic, and Neutral Drugs
- Assessment of Extent of Underprediction in Relation to fup and BDDCS
- Current Status of In Vitro Prediction of Clearance
- Future Prospects to Refine In Vitro Prediction of Clearance
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
- PDF + SI
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