Graduate School of Pharmaceutical Sciences (M.A.), Medicinal Research Laboratories (H.F.), Center for Clinical Pharmacy and Clinical Sciences (M.A., K.A.), Laboratory of Medicinal Chemistry (H.F.), and Department of Pharmaceutics (T.I., R.F.), School of Pharmacy, Kitasato University, Tokyo, Japan; Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (T.F., M.N.)

Graduate School of Pharmaceutical Sciences (M.A.), Medicinal Research Laboratories (H.F.), Center for Clinical Pharmacy and Clinical Sciences (M.A., K.A.), Laboratory of Medicinal Chemistry (H.F.), and Department of Pharmaceutics (T.I., R.F.), School of Pharmacy, Kitasato University, Tokyo, Japan; Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (T.F., M.N.)

Graduate School of Pharmaceutical Sciences (M.A.), Medicinal Research Laboratories (H.F.), Center for Clinical Pharmacy and Clinical Sciences (M.A., K.A.), Laboratory of Medicinal Chemistry (H.F.), and Department of Pharmaceutics (T.I., R.F.), School of Pharmacy, Kitasato University, Tokyo, Japan; Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (T.F., M.N.)

Graduate School of Pharmaceutical Sciences (M.A.), Medicinal Research Laboratories (H.F.), Center for Clinical Pharmacy and Clinical Sciences (M.A., K.A.), Laboratory of Medicinal Chemistry (H.F.), and Department of Pharmaceutics (T.I., R.F.), School of Pharmacy, Kitasato University, Tokyo, Japan; Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (T.F., M.N.)

Graduate School of Pharmaceutical Sciences (M.A.), Medicinal Research Laboratories (H.F.), Center for Clinical Pharmacy and Clinical Sciences (M.A., K.A.), Laboratory of Medicinal Chemistry (H.F.), and Department of Pharmaceutics (T.I., R.F.), School of Pharmacy, Kitasato University, Tokyo, Japan; Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (T.F., M.N.)

Graduate School of Pharmaceutical Sciences (M.A.), Medicinal Research Laboratories (H.F.), Center for Clinical Pharmacy and Clinical Sciences (M.A., K.A.), Laboratory of Medicinal Chemistry (H.F.), and Department of Pharmaceutics (T.I., R.F.), School of Pharmacy, Kitasato University, Tokyo, Japan; Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (T.F., M.N.)

Graduate School of Pharmaceutical Sciences (M.A.), Medicinal Research Laboratories (H.F.), Center for Clinical Pharmacy and Clinical Sciences (M.A., K.A.), Laboratory of Medicinal Chemistry (H.F.), and Department of Pharmaceutics (T.I., R.F.), School of Pharmacy, Kitasato University, Tokyo, Japan; Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan (T.F., M.N.)