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Research ArticleArticle

Critical Impact of Drug-Drug Interactions via Intestinal CYP3A in the Risk Assessment of Weak Perpetrators Using Physiologically Based Pharmacokinetic Models

Makiko Yamada, Shin-ichi Inoue, Daisuke Sugiyama, Yumi Nishiya, Tomoko Ishizuka, Akiko Watanabe, Kengo Watanabe, Shinji Yamashita and Nobuaki Watanabe
Drug Metabolism and Disposition April 2020, 48 (4) 288-296; DOI: https://doi.org/10.1124/dmd.119.089599

Article Information

vol. 48 no. 4 288-296
DOI 
https://doi.org/10.1124/dmd.119.089599
PubMed 
31996361
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 11, 2019
  • Accepted January 18, 2020
  • Published online March 10, 2020.

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Copyright & Usage 
Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Makiko Yamada,
  2. Shin-ichi Inoue,
  3. Daisuke Sugiyama,
  4. Yumi Nishiya,
  5. Tomoko Ishizuka,
  6. Akiko Watanabe,
  7. Kengo Watanabe,
  8. Shinji Yamashita, and
  9. Nobuaki Watanabe
  1. Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan (M.Y., S.I., D.S., Y.N., T.I., A.W., K.W., N.W.) and Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan (S.Y.)
  1. Address correspondence to:
    Makiko Yamada, Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. E-mail: yamada.makiko.jr{at}daiichisankyo.co.jp
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PBPK Modeling of Weak Perpetrators via Intestinal CYP3A

Makiko Yamada, Shin-ichi Inoue, Daisuke Sugiyama, Yumi Nishiya, Tomoko Ishizuka, Akiko Watanabe, Kengo Watanabe, Shinji Yamashita and Nobuaki Watanabe
Drug Metabolism and Disposition April 1, 2020, 48 (4) 288-296; DOI: https://doi.org/10.1124/dmd.119.089599
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