Extrapolation of In Vivo Hepatic Clearance from In Vitro Uptake Clearance by Suspended Human Hepatocytes (IVIVE) for Anionic Drugs with High Binding to Human Albumin: Improvement of IVIVE by Considering the "Albumin-Mediated" Hepatic Uptake Mechanism Based on the facilitated-dissociation Model

Data Supplement

• Supplemental Data -

  Supplemental Figure 1 - Time profiles of the uptake of OATP substrates in suspended human hepatocytes with various concentration of human serum albumin (HSA)
  Supplemental Figure 2 - The hepatic unbound uptake clearance in the presence of the albumin ( PSu,inf (+) ) of clinical OATPs substrates in suspended human hepatocytes
  Supplemental Table 1 - LC–MS/MS conditions for eleven drugs
  Supplemental Table 2 - The reported values of Km and the uptake clearance of eleven drugs in suspended hepatocytes
  Supplemental Table 3 - Sources of in vitro and in vivo parameters