Induction of Human Intestinal and Hepatic Organic Anion Transporting Polypeptides; Where is the Evidence for its Relevance in Drug-Drug Interactions?

Data Supplement

• Supplemental Tables -

  Supplementary Table 1 - Drug interaction between itraconazole with pravastatin compared to coproporphyrin isomers and digoxin.

  Supplementary Table 2 - Clinical assessment of rifampicin as inhibitor of CYP3A and Pgp; digoxin and dabigatran etexilate as Pgp probes; and midazolam as CYP3A probe.

  Supplementary Table 3 - Rifampicin and its metabolites as solute carrier, Pgp and MRP2 substrates in vitro (Pfizer, unpublished data).

  Supplementary Table 4 - Impact of various known CYP3A inducers on the PK of Pgp probe drugs digoxin and dabigatran.