Impact of P-glycoprotein-mediated active efflux on drug distribution into lumbar cerebrospinal fluid in nonhuman primates

Data Supplement

• Supplemental Figure 1 -

  Supplementary Figure 1 - Plasma concentration-time profile of zosuquidar in monkey after a single intravenous administration.
  

• Supplemental Table 1 -

  Supplementary Table 1 - Efflux ratio and % of control in in vitro P-gp inhibition study. 

• Supplemental Table 2 -

  Supplementary Table 2 - Comparison of Kp,uu,lumbar CSF values with CCSF/Cu,plasma at 24 hours after starting infusion.