Stereoselectivity and isotope effects associated with cytochrome P450-catalyzed oxidation of (S)-nicotine. The possibility of initial hydrogen atom abstraction in the formation of the delta 1', 5-nicotinium ion.

T J Carlson; J P Jones; L Peterson; N Castagnoli; K R Iyer; W F Trager

Abstract

Stereoselectivity and isotope effects associated with cytochrome P450-catalyzed oxidation of (S)-nicotine. The possibility of initial hydrogen atom abstraction in the formation of the delta 1', 5-nicotinium ion.

T J Carlson, J P Jones, L Peterson, N Castagnoli Jr, K R Iyer and W F Trager

Drug Metabolism and Disposition July 1995, 23 (7) 749-756;

T J Carlson

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J P Jones

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L Peterson

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N Castagnoli Jr

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K R Iyer

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W F Trager

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Drug Metabolism and Disposition

Vol. 23, Issue 7

1 Jul 1995

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Abstract

Stereoselectivity and isotope effects associated with cytochrome P450-catalyzed oxidation of (S)-nicotine. The possibility of initial hydrogen atom abstraction in the formation of the delta 1', 5-nicotinium ion.

T J Carlson, J P Jones, L Peterson, N Castagnoli, K R Iyer and W F Trager

Drug Metabolism and Disposition July 1, 1995, 23 (7) 749-756;

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Abstract

Stereoselectivity and isotope effects associated with cytochrome P450-catalyzed oxidation of (S)-nicotine. The possibility of initial hydrogen atom abstraction in the formation of the delta 1', 5-nicotinium ion.

T J Carlson, J P Jones, L Peterson, N Castagnoli, K R Iyer and W F Trager

Drug Metabolism and Disposition July 1, 1995, 23 (7) 749-756;

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Stereoselectivity and isotope effects associated with cytochrome P450-catalyzed oxidation of (S)-nicotine. The possibility of initial hydrogen atom abstraction in the formation of the delta 1', 5-nicotinium ion.

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Stereoselectivity and isotope effects associated with cytochrome P450-catalyzed oxidation of (S)-nicotine. The possibility of initial hydrogen atom abstraction in the formation of the delta 1', 5-nicotinium ion.

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