Table of Contents

Articles

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  DETECTION OF GLUTATHIONE CONJUGATES DERIVED FROM 4-IPOMEANOL METABOLISM IN BILE OF RATS BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY

  Teresa M. Alvarez-Diez and Jiang Zheng

  Drug Metabolism and Disposition December 2004, 32 (12) 1345-1350; DOI: https://doi.org/10.1124/dmd.104.000406
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  IDENTIFICATION AND CHARACTERIZATION OF POTENT CYP3A4 INHIBITORS IN SCHISANDRA FRUIT EXTRACT

  Hiroshi Iwata, Yasuhiro Tezuka, Shigetoshi Kadota, Akira Hiratsuka and Tadashi Watabe

  Drug Metabolism and Disposition December 2004, 32 (12) 1351-1358; DOI: https://doi.org/10.1124/dmd.104.000646
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  THE CHIMPANZEE (PAN TROGLODYTES) AS A PHARMACOKINETIC MODEL FOR SELECTION OF DRUG CANDIDATES: MODEL CHARACTERIZATION AND APPLICATION

  Harvey Wong, Scott J. Grossman, Stephen A. Bai, Sharon Diamond, Matthew R. Wright, James E. Grace, Mingxin Qian, Kan He, Krishnaswamy Yeleswaram and David D. Christ

  Drug Metabolism and Disposition December 2004, 32 (12) 1359-1369; DOI: https://doi.org/10.1124/dmd.104.000943
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  EFFECTS OF AVASIMIBE ON CYTOCHROME P450 2C9 EXPRESSION IN VITRO AND IN VIVO

  Jasminder Sahi, Ralph H. Stern, Mark A. Milad, Kelly A. Rose, Gordon Gibson, Xianxian Zheng, Linda Stilgenbauer, Nalini Sadagopan, Summer Jolley, Darryl Gilbert and Edward L. LeCluyse

  Drug Metabolism and Disposition December 2004, 32 (12) 1370-1376; DOI: https://doi.org/10.1124/dmd.104.000208
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  HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS

  Thomas Walle, Faye Hsieh, Mark H. DeLegge, John E. Oatis and U. Kristina Walle

  Drug Metabolism and Disposition December 2004, 32 (12) 1377-1382; DOI: https://doi.org/10.1124/dmd.104.000885
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  MECHANISM OF THE DRUG INTERACTION BETWEEN VALPROIC ACID AND CARBAPENEM ANTIBIOTICS IN MONKEYS AND RATS

  Yoshitsugu Nakajima, Minoru Mizobuchi, Masahiro Nakamura, Hidetoshi Takagi, Haruhisa Inagaki, Goro Kominami, Masahiro Koike and Toshiro Yamaguchi

  Drug Metabolism and Disposition December 2004, 32 (12) 1383-1391; DOI: https://doi.org/10.1124/dmd.104.000661
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  FLUORINATED 2-(4-AMINO-3-METHYLPHENYL)BENZOTHIAZOLES INDUCE CYP1A1 EXPRESSION, BECOME METABOLIZED, AND BIND TO MACROMOLECULES IN SENSITIVE HUMAN CANCER CELLS

  Eileen Brantley, Valentina Trapani, Michael C. Alley, Curtis D. Hose, Tracey D. Bradshaw, Malcolm F. G. Stevens, Edward A. Sausville and Sherman F. Stinson

  Drug Metabolism and Disposition December 2004, 32 (12) 1392-1401; DOI: https://doi.org/10.1124/dmd.104.001057
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  EXPRESSION OF HUMAN CYTOCHROMES P450 IN CHIMERIC MICE WITH HUMANIZED LIVER

  Miki Katoh, Tomohito Matsui, Miki Nakajima, Chise Tateno, Miho Kataoka, Yoshinori Soeno, Toru Horie, Kazuhide Iwasaki, Katsutoshi Yoshizato and Tsuyoshi Yokoi

  Drug Metabolism and Disposition December 2004, 32 (12) 1402-1410; DOI: https://doi.org/10.1124/dmd.104.001347
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  UTILITY OF RECOMBINANT ENZYME KINETICS IN PREDICTION OF HUMAN CLEARANCE: IMPACT OF VARIABILITY, CYP3A5, AND CYP2C19 ON CYP3A4 PROBE SUBSTRATES

  Aleksandra Galetin, Caroline Brown, David Hallifax, Kiyomi Ito and J. Brian Houston

  Drug Metabolism and Disposition December 2004, 32 (12) 1411-1420; DOI: https://doi.org/10.1124/dmd.104.000844
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  THE RATE OF GASTRIC EMPTYING DETERMINES THE TIMING BUT NOT THE EXTENT OF ORAL TACROLIMUS ABSORPTION: SIMULTANEOUS MEASUREMENT OF DRUG EXPOSURE AND GASTRIC EMPTYING BY CARBON-14-OCTANOIC ACID BREATH TEST IN STABLE RENAL ALLOGRAFT RECIPIENTS

  Dirk R. J. Kuypers, Kathleen Claes, P. Evenepoel, B. Maes and Yves Vanrenterghem

  Drug Metabolism and Disposition December 2004, 32 (12) 1421-1425; DOI: https://doi.org/10.1124/dmd.104.001503
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  ASSESSMENT OF CATECHOL INDUCTION AND GLUCURONIDATION IN RAT LIVER MICROSOMES

  Eivor Elovaara, Jouni Mikkola, Leena Luukkanen, Laurence Antonio, Sylvie Fournel-Gigleux, Brian Burchell, Jacques Magdalou and Jyrki Taskinen

  Drug Metabolism and Disposition December 2004, 32 (12) 1426-1433; DOI: https://doi.org/10.1124/dmd.104.000992
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  EVIDENCE OF SIGNIFICANT CONTRIBUTION FROM CYP3A5 TO HEPATIC DRUG METABOLISM

  Weili Huang, Yvonne S. Lin, Donavon J. McConn, Justina C. Calamia, Rheem A. Totah, Nina Isoherranen, Mary Glodowski and Kenneth E. Thummel

  Drug Metabolism and Disposition December 2004, 32 (12) 1434-1445; DOI: https://doi.org/10.1124/dmd.104.001313
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  SHORT-TERM INHIBITORY EFFECTS OF NITRIC OXIDE ON CYTOCHROME P450-MEDIATED DRUG METABOLISM: TIME DEPENDENCY AND REVERSIBILITY PROFILES IN ISOLATED PERFUSED RAT LIVERS

  Ragini Vuppugalla and Reza Mehvar

  Drug Metabolism and Disposition December 2004, 32 (12) 1446-1454; DOI: https://doi.org/10.1124/dmd.104.001487
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  TISSUE DISTRIBUTION OF CONCENTRATIVE AND EQUILIBRATIVE NUCLEOSIDE TRANSPORTERS IN MALE AND FEMALE RATS AND MICE

  Hong Lu, Chuan Chen and Curtis Klaassen

  Drug Metabolism and Disposition December 2004, 32 (12) 1455-1461; DOI: https://doi.org/10.1124/dmd.104.001123
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  CONVERSION OF THE HIV PROTEASE INHIBITOR NELFINAVIR TO A BIOACTIVE METABOLITE BY HUMAN LIVER CYP2C19

  Vandana N. Hirani, Judy L. Raucy and Jerome M. Lasker

  Drug Metabolism and Disposition December 2004, 32 (12) 1462-1467; DOI: https://doi.org/10.1124/dmd.104.001743
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  IN VITRO AND IN VIVO CORRELATION OF THE INHIBITORY EFFECT OF CYCLOSPORIN A ON THE TRANSPORTER-MEDIATED HEPATIC UPTAKE OF CERIVASTATIN IN RATS

  Yoshihisa Shitara, Masaru Hirano, Yasuhisa Adachi, Tomoo Itoh, Hitoshi Sato and Yuichi Sugiyama

  Drug Metabolism and Disposition December 2004, 32 (12) 1468-1475; DOI: https://doi.org/10.1124/dmd.32.12.1468
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  IDENTIFICATION OF THE RABBIT LIVER UDP-GLUCURONOSYLTRANSFERASE CATALYZING THE GLUCURONIDATION OF 4-ETHOXYPHENYLUREA (DULCIN)

  Yoshihiro Uesawa, Adam G. Staines, Audrey O'Sullivan, Kiminori Mohri and Brian Burchell

  Drug Metabolism and Disposition December 2004, 32 (12) 1476-1481; DOI: https://doi.org/10.1124/dmd.104.001206
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  IDENTIFICATION OF GLUTATHIONE-DERIVED METABOLITES FROM AN IP RECEPTOR ANTAGONIST

  William L. Fitch, Pamela W. Berry, Yaping Tu, Ali Tabatabaei, Lee Lowrie, Francisco Lopez-Tapia, Yanzhou Liu, Dov Nitzan, Mohammad R. Masjedizadeh and Aravamuthan Varadarajan

  Drug Metabolism and Disposition December 2004, 32 (12) 1482-1490; DOI: https://doi.org/10.1124/dmd.104.000471
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  METABOLISM AND DISPOSITION OF CALCIMIMETIC AGENT CINACALCET HCL IN HUMANS AND ANIMAL MODELS

  Gondi N. Kumar, Christopher Sproul, Leszek Poppe, Sharon Turner, Mark Gohdes, Hesham Ghoborah, Desmond Padhi and Lorin Roskos

  Drug Metabolism and Disposition December 2004, 32 (12) 1491-1500; DOI: https://doi.org/10.1124/dmd.104.000604
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  INTERACTIONS OF THE STEREOISOMERS OF α-HYDROXYTAMOXIFEN WITH HUMAN HYDROXYSTEROID SULFOTRANSFERASE SULT2A1 AND RAT HYDROXYSTEROID SULFOTRANSFERASE STA

  T. Idil Apak and Michael W. Duffel

  Drug Metabolism and Disposition December 2004, 32 (12) 1501-1508; DOI: https://doi.org/10.1124/dmd.104.000919
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  USE OF A BENZYLOXY-SUBSTITUTED LACTONE CYCLOOXYGENASE-2 INHIBITOR AS A SELECTIVE FLUORESCENT PROBE FOR CYP3A ACTIVITY IN PRIMARY CULTURED RAT AND HUMAN HEPATOCYTES

  Deborah A. Nicoll-Griffith, Nathalie Chauret, Robert Houle, Stephen H. Day, Michelle D'Antoni and José M. Silva

  Drug Metabolism and Disposition December 2004, 32 (12) 1509-1515; DOI: https://doi.org/10.1124/dmd.32.12.1509
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  IDENTIFICATION OF CRITICAL AMINO ACID RESIDUES OF HUMAN CYP2A13 FOR THE METABOLIC ACTIVATION OF 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE, A TOBACCO-SPECIFIC CARCINOGEN

  Xiao-Yang He, Jian Shen, Xinxin Ding, Anthony Y. H. Lu and Jun-Yan Hong

  Drug Metabolism and Disposition December 2004, 32 (12) 1516-1521; DOI: https://doi.org/10.1124/dmd.104.001370