Drug Metabolism and Disposition: 33 (1)

January 01, 2005; Volume 33,Issue 1

Commentary

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THE ROLES OF TRANSPORTERS AND ENZYMES IN HEPATIC DRUG PROCESSING
Lichuan Liu and K. Sandy Pang

Drug Metabolism and Disposition January 2005, 33 (1) 1-9; DOI: https://doi.org/10.1124/dmd.104.001149

The 2004 Bernard B. Brodie Award Lecture

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STRUCTURAL AND FUNCTIONAL DIVERSITY IN HEME MONOOXYGENASES
Thomas L. Poulos

Drug Metabolism and Disposition January 2005, 33 (1) 10-18; DOI: https://doi.org/10.1124/dmd.104.002071

Short Communication

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LACK OF EVIDENCE FOR INDUCTION OF CYP2B1, CYP3A23, AND CYP1A2 GENE EXPRESSION BY Panax ginseng AND Panax quinquefolius EXTRACTS IN ADULT RATS AND PRIMARY CULTURES OF RAT HEPATOCYTES
Chia-ting Yu, Jie Chen, Xiao Wei Teng, Vincent Tong and Thomas K. H. Chang

Drug Metabolism and Disposition January 2005, 33 (1) 19-22; DOI: https://doi.org/10.1124/dmd.104.001917

Articles

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TRANS-3′-HYDROXYCOTININE O- AND N-GLUCURONIDATIONS IN HUMAN LIVER MICROSOMES
Hiroyuki Yamanaka, Miki Nakajima, Miki Katoh, Ayano Kanoh, Osamu Tamura, Hiroyuki Ishibashi and Tsuyoshi Yokoi

Drug Metabolism and Disposition January 2005, 33 (1) 23-30; DOI: https://doi.org/10.1124/dmd.104.001701
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EXPRESSION, LOCALIZATION, AND FUNCTION OF THE CARNITINE TRANSPORTER OCTN2 (SLC22A5) IN HUMAN PLACENTA
Markus Grube, Henriette Meyer zu Schwabedissen, Katrin Draber, Damaris Präger, Klaus-Uwe Möritz, Knud Linnemann, Christoph Fusch, Gabriele Jedlitschky and Heyo K. Kroemer

Drug Metabolism and Disposition January 2005, 33 (1) 31-37; DOI: https://doi.org/10.1124/dmd.104.001560
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HIGH VOLUME BIOASSAYS TO ASSESS CYP3A4-MEDIATED DRUG INTERACTIONS: INDUCTION AND INHIBITION IN A SINGLE CELL LINE
Mei-Fei Yueh, Marleen Kawahara and Judy Raucy

Drug Metabolism and Disposition January 2005, 33 (1) 38-48; DOI: https://doi.org/10.1124/dmd.104.001594
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PHARMACOKINETICS AND METABOLISM OF APIGENIN IN FEMALE AND MALE RATS AFTER A SINGLE ORAL ADMINISTRATION
Angéline Gradolatto, Jean-Philippe Basly, Raymond Berges, Caroline Teyssier, Marie-Christine Chagnon, Marie-Héléne Siess and Marie-Chantal Canivenc-Lavier

Drug Metabolism and Disposition January 2005, 33 (1) 49-54; DOI: https://doi.org/10.1124/dmd.104.000893
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BISPHENOL A GLUCURONIDATION AND EXCRETION IN LIVER OF PREGNANT AND NONPREGNANT FEMALE RATS
Hiroki Inoue, Akio Tsuruta, Satoko Kudo, Takako Ishii, Yusuke Fukushima, Hidetomo Iwano, Hiroshi Yokota and Seiyu Kato

Drug Metabolism and Disposition January 2005, 33 (1) 55-59; DOI: https://doi.org/10.1124/dmd.104.001537
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CHARACTERIZATION OF AFLOQUALONE N-GLUCURONIDATION: SPECIES DIFFERENCES AND IDENTIFICATION OF HUMAN UDP-GLUCURONOSYLTRANSFERASE ISOFORM(S)
Hidefumi Kaji and Toshiyuki Kume

Drug Metabolism and Disposition January 2005, 33 (1) 60-67; DOI: https://doi.org/10.1124/dmd.104.001925
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THE CONTRIBUTION OF FETAL METABOLISM TO THE DISPOSITION OF MORPHINE
Marianne Garland, Kirsten M. Abildskov, Tung-wah Kiu, Salha S. Daniel and Raymond I. Stark

Drug Metabolism and Disposition January 2005, 33 (1) 68-76; DOI: https://doi.org/10.1124/dmd.104.001388
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ANALYSIS OF SUBSTRATE SPECIFICITIES AND TISSUE EXPRESSION OF RAT UDP-GLUCURONOSYLTRANSFERASES UGT1A7 AND UGT1A8
Laura J. Webb, Kristini K. Miles, Diana J. Auyeung, Fay K. Kessler and Joseph K. Ritter

Drug Metabolism and Disposition January 2005, 33 (1) 77-82; DOI: https://doi.org/10.1124/dmd.104.001321
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METABOLISM, PHARMACOKINETICS, AND PROTEIN COVALENT BINDING OF RADIOLABELED MAXIPOST (BMS-204352) IN HUMANS
Donglu Zhang, Rajesh Krishna, Lifei Wang, Jianing Zeng, James Mitroka, Renke Dai, Narayanan Narasimhan, Richard A. Reeves, Nuggehally R. Srinivas and Lewis J. Klunk

Drug Metabolism and Disposition January 2005, 33 (1) 83-93; DOI: https://doi.org/10.1124/dmd.104.001412
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FUNCTIONAL ASSESSMENT OF ABCG2 (BCRP) GENE POLYMORPHISMS TO PROTEIN EXPRESSION IN HUMAN PLACENTA
Daisuke Kobayashi, Ichiro Ieiri, Takeshi Hirota, Hiroshi Takane, Shinji Maegawa, Junzo Kigawa, Hiroshi Suzuki, Eiji Nanba, Mitsuo Oshimura, Naoki Terakawa, Kenji Otsubo, Kazunori Mine and Yuichi Sugiyama

Drug Metabolism and Disposition January 2005, 33 (1) 94-101; DOI: https://doi.org/10.1124/dmd.104.001628
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METABOLISM OF 26,26,26,27,27,27-F₆-1α,23S,25-TRIHYDROXYVITAMIN D₃ BY HUMAN UDP-GLUCURONOSYLTRANSFERASE 1A3^*
Noriyuki Kasai, Toshiyuki Sakaki, Raku Shinkyo, Shin-ichi Ikushiro, Takashi Iyanagi, Miho Ohta and Kuniyo Inouye

Drug Metabolism and Disposition January 2005, 33 (1) 102-107; DOI: https://doi.org/10.1124/dmd.104.002303
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LIVER GRAFTS PRESERVED IN CELSIOR SOLUTION AS SOURCE OF HEPATOCYTES FOR DRUG METABOLISM STUDIES: COMPARISON WITH SURGICAL LIVER BIOPSIES
M. Teresa Donato, Alfonso Serralta, Nuria Jiménez, Gabriela Pérez, José V. Castell, José Mir and M. José Gómez-Lechón

Drug Metabolism and Disposition January 2005, 33 (1) 108-114; DOI: https://doi.org/10.1124/dmd.104.001545
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PREDICTION OF IN VITRO INTRINSIC CLEARANCE FROM HEPATOCYTES: COMPARISON OF SUSPENSIONS AND MONOLAYER CULTURES
Sarah J. Griffin and J. Brian Houston

Drug Metabolism and Disposition January 2005, 33 (1) 115-120; DOI: https://doi.org/10.1124/dmd.33.1.115
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METABOLIC ACTIVATION OF FLUOROPYRROLIDINE DIPEPTIDYL PEPTIDASE-IV INHIBITORS BY RAT LIVER MICROSOMES
Shiyao Xu, Bing Zhu, Yohannes Teffera, Deborah E. Pan, Charles G. Caldwell, George Doss, Ralph A. Stearns, David C. Evans and Maria G. Beconi

Drug Metabolism and Disposition January 2005, 33 (1) 121-130; DOI: https://doi.org/10.1124/dmd.104.001842
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TIME-DEPENDENT INHIBITION AND TETRAHYDROBIOPTERIN DEPLETION OF ENDOTHELIAL NITRIC-OXIDE SYNTHASE CAUSED BY CIGARETTES
Ezra R. Lowe, Andrew C. Everett, Anthony J. Lee, Miranda Lau, Anwar Y. Dunbar, Vladimir Berka, Ah-lim Tsai and Yoichi Osawa

Drug Metabolism and Disposition January 2005, 33 (1) 131-138; DOI: https://doi.org/10.1124/dmd.104.001891
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IDENTIFICATION OF THE UDP-GLUCURONOSYLTRANSFERASE ISOFORMS INVOLVED IN MYCOPHENOLIC ACID PHASE II METABOLISM
Nicolas Picard, Damrong Ratanasavanh, Aurélie Prémaud, Yonnick Le Meur and Pierre Marquet

Drug Metabolism and Disposition January 2005, 33 (1) 139-146; DOI: https://doi.org/10.1124/dmd.104.001651
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REGULATION OF GLUCOCORTICOID-INDUCIBLE HYDROXYSTEROID SULFOTRANSFERASE (SULT2A-40/41) GENE TRANSCRIPTION IN PRIMARY CULTURED RAT HEPATOCYTES: ROLE OF CCAAT/ENHANCER-BINDING PROTEIN LIVER-ENRICHED TRANSCRIPTION FACTORS
Hai-Lin Fang, Masumeh Abdolalipour, Zhengbo Duanmu, Jeffrey R. Smigelski, Amy Weckle, Thomas A. Kocarek and Melissa Runge-Morris

Drug Metabolism and Disposition January 2005, 33 (1) 147-156; DOI: https://doi.org/10.1124/dmd.104.000281
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INTERACTIONS BETWEEN CYP2C9 AND CYP2C19 IN RECONSTITUTED BINARY SYSTEMS INFLUENCE THEIR CATALYTIC ACTIVITY: POSSIBLE RATIONALE FOR THE INABILITY OF CYP2C19 TO CATALYZE METHOXYCHLOR DEMETHYLATION IN HUMAN LIVER MICROSOMES
Eszter Hazai and David Kupfer

Drug Metabolism and Disposition January 2005, 33 (1) 157-164; DOI: https://doi.org/10.1124/dmd.104.001578
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THE IMPACT OF P-GLYCOPROTEIN ON THE DISPOSITION OF DRUGS TARGETED FOR INDICATIONS OF THE CENTRAL NERVOUS SYSTEM: EVALUATION USING THE MDR1A/1B KNOCKOUT MOUSE MODEL
Angela Doran, R. Scott Obach, Bill J. Smith, Natilie A. Hosea, Stacey Becker, Ernesto Callegari, Cuiping Chen, Xi Chen, Edna Choo, Julie Cianfrogna, Loretta M. Cox, John P. Gibbs, Megan A. Gibbs, Heather Hatch, Cornelis E.C.A. Hop, Ilana N. Kasman, Jennifer LaPerle, JianHua Liu, Xingrong Liu, Michael Logman, Debra Maclin, Frank M. Nedza, Frederick Nelson, Emily Olson, Sandhya Rahematpura, David Raunig, Sabrinia Rogers, Kari Schmidt, Douglas K. Spracklin, Mark Szewc, Matthew Troutman, Elaine Tseng, Meihua Tu, Jeffrey W. Van Deusen, Karthik Venkatakrishnan, Gary Walens, Ellen Q. Wang, Diane Wong, Adam S. Yasgar and Chenghong Zhang

Drug Metabolism and Disposition January 2005, 33 (1) 165-174; DOI: https://doi.org/10.1124/dmd.104.001230
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RELATIONSHIP BETWEEN EXPOSURE AND NONSPECIFIC BINDING OF THIRTY-THREE CENTRAL NERVOUS SYSTEM DRUGS IN MICE
Tristan S. Maurer, Demetria B. DeBartolo, David A. Tess and Dennis O. Scott

Drug Metabolism and Disposition January 2005, 33 (1) 175-181; DOI: https://doi.org/10.1124/dmd.104.001222
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XENOBIOTIC AND ENDOBIOTIC TRANSPORTER MRNA EXPRESSION IN THE BLOOD-TESTIS BARRIER
Lisa M. Augustine, Robert J. Markelewicz, Kim Boekelheide and Nathan J. Cherrington

Drug Metabolism and Disposition January 2005, 33 (1) 182-189; DOI: https://doi.org/10.1124/dmd.104.001024
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METABOLISM, PHARMACOKINETICS, TISSUE DISTRIBUTION, AND EXCRETION OF [¹⁴C]CP-424391 IN RATS
S. Cyrus Khojasteh-Bakht, John P. O'Donnell, Hassan G. Fouda and Michael J. Potchoiba

Drug Metabolism and Disposition January 2005, 33 (1) 190-199; DOI: https://doi.org/10.1124/dmd.104.001065

Erratum

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CORRECTION TO “TISSUE DISTRIBUTION, STABILITY, AND PHARMACOKINETICS OF APO2 LIGAND/TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND IN HUMAN COLON CARCINOMA COLO205 TUMOR-BEARING MICE”
Drug Metabolism and Disposition January 2005, 33 (1) 200-201; DOI: https://doi.org/10.1124/dmd.33.1.200

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The 2004 Bernard B. Brodie Award Lecture

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