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P-glycoprotein Has Differential Effects on the Disposition of Statin Acid and Lactone Forms in mdr1a/b Knockout and Wild-Type Mice

Cuiping Chen, Jian Lin, Teresa Smolarek and Larry Tremaine
Drug Metabolism and Disposition October 2007, 35 (10) 1725-1729; DOI: https://doi.org/10.1124/dmd.107.015677

Article Information

vol. 35 no. 10 1725-1729
DOI 
https://doi.org/10.1124/dmd.107.015677
PubMed 
17640956
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received March 7, 2007
  • Accepted July 18, 2007
  • Published online September 24, 2007.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Cuiping Chen,
  2. Jian Lin,
  3. Teresa Smolarek and
  4. Larry Tremaine
  1. Global Preclinical Development, Johnson & Johnson, Mountain View, California (C.C.); and Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, Pfizer Inc., Groton, Connecticut (J.L., T.S., L.T.)
  1. Address correspondence to:
    Dr. Cuiping Chen, Global Preclinical Development, Johnson & Johnson, Mail Stop M3A, 1900 Charleston Rd., Mountain View, CA 94039. E-mail: tchen3{at}alzus.jnj.com
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OtherShort Communication

P-glycoprotein Has Differential Effects on the Disposition of Statin Acid and Lactone Forms in mdr1a/b Knockout and Wild-Type Mice

Cuiping Chen, Jian Lin, Teresa Smolarek and Larry Tremaine
Drug Metabolism and Disposition October 1, 2007, 35 (10) 1725-1729; DOI: https://doi.org/10.1124/dmd.107.015677
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