Advertisement
Research ArticleArticle

Evaluation of Cynomolgus Monkey Pregnane X Receptor, Primary Hepatocyte, and in Vivo Pharmacokinetic Changes in Predicting Human CYP3A4 Induction

Sean Kim, Joseph E. Dinchuk, Monique N. Anthony, Tami Orcutt, Mary E. Zoeckler, Mary B. Sauer, Kathleen W. Mosure, Ragini Vuppugalla, James E. Grace Jr., Jean Simmermacher, Heidi A. Dulac, Jennifer Pizzano and Michael Sinz
Drug Metabolism and Disposition January 2010, 38 (1) 16-24; DOI: https://doi.org/10.1124/dmd.109.029637

Article Information

vol. 38 no. 1 16-24
DOI 
https://doi.org/10.1124/dmd.109.029637
PubMed 
19833845
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 11, 2009
  • Accepted October 7, 2009
  • Published online December 15, 2009.

Article Versions

Copyright & Usage 
Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Sean Kim,
  2. Joseph E. Dinchuk,
  3. Monique N. Anthony,
  4. Tami Orcutt,
  5. Mary E. Zoeckler,
  6. Mary B. Sauer,
  7. Kathleen W. Mosure,
  8. Ragini Vuppugalla,
  9. James E. Grace Jr.,
  10. Jean Simmermacher,
  11. Heidi A. Dulac,
  12. Jennifer Pizzano and
  13. Michael Sinz
  1. Metabolism and Pharmacokinetics (S.K., M.E.Z., K.W.M., J.E.G., J.S., M.S.), Lead Discovery (M.N.A.), Discovery Toxicology (T.O., J.P.), and Veterinary Science (M.B.S., H.A.D.), Bristol-Myers Squibb Company, Wallingford, Connecticut; and Discovery Biology-Oncology (J.E.D.) and Metabolism and Pharmacokinetics (R.V.), Bristol-Myers Squibb Company, Lawrenceville, New Jersey
  1. Address correspondence to:
    Sean Kim,
    Metabolism and Pharmacokinetics, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492.
    E-mail: sean.kim{at}bms.com
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: August 2017 to December 2024

AbstractFullPdf
Aug 201751218
Sep 20171419236
Oct 201708719
Nov 201783318
Dec 201712413
Jan 20181279
Feb 20181146
Mar 201812214
Apr 201823414
May 201833525
Jun 201872810
Jul 20181209
Aug 20181156
Sep 2018268
Oct 20183610
Nov 201822014
Dec 201814114
Jan 20192854
Feb 20191414
Mar 201917110
Apr 201941513
May 20192127
Jun 2019241019
Jul 20192914
Aug 201912311
Oct 2019201215
Nov 201930310
Dec 20193559
Jan 20201554
Feb 20201923
Mar 20202599
May 20201316
Jun 20201435
Jul 20201062
Aug 2020415
Sep 20201201
Oct 20201146
Nov 20202736
Dec 20202666
Jan 202128108
Feb 20212187
Mar 202138610
Apr 20213647
May 20213388
Jun 20216252
Jul 20212248
Aug 20212476
Sep 20211424
Oct 20211234
Nov 20213349
Dec 20212153
Jan 20222887
Feb 20221245
Mar 20222435
Apr 20221364
May 20221157
Jun 20221622
Jul 20221118
Aug 20221824
Sep 20221481
Oct 202214135
Nov 202226410
Dec 20221226
Jan 20232432
Feb 20231895
Mar 2023712
Apr 202313411
May 202328914
Jun 2023921
Jul 20233069
Aug 20232850
Sep 202339913
Oct 202340311
Nov 20236047
Dec 20234890
Jan 20245074
Feb 202422194
Mar 20241420
Apr 202437135
May 202434132
Jun 20243998
Jul 202445238
Aug 20242895
Sep 20244174
Oct 20241534
Nov 20243315
Dec 20242925

Back to top

In this issue

Download PDF
Article Alerts
Email Article
Citation Tools

Research ArticleArticle

Evaluation of Cynomolgus Monkey Pregnane X Receptor, Primary Hepatocyte, and in Vivo Pharmacokinetic Changes in Predicting Human CYP3A4 Induction

Sean Kim, Joseph E. Dinchuk, Monique N. Anthony, Tami Orcutt, Mary E. Zoeckler, Mary B. Sauer, Kathleen W. Mosure, Ragini Vuppugalla, James E. Grace, Jean Simmermacher, Heidi A. Dulac, Jennifer Pizzano and Michael Sinz
Drug Metabolism and Disposition January 1, 2010, 38 (1) 16-24; DOI: https://doi.org/10.1124/dmd.109.029637
Twitter logo Facebook logo Mendeley logo

Jump to section

Advertisement