Evaluation of Cynomolgus Monkey Pregnane X Receptor, Primary Hepatocyte, and in Vivo Pharmacokinetic Changes in Predicting Human CYP3A4 Induction

Sean Kim; Joseph E. Dinchuk; Monique N. Anthony; Tami Orcutt; Mary E. Zoeckler; Mary B. Sauer; Kathleen W. Mosure; Ragini Vuppugalla; James E. Grace; Jean Simmermacher; Heidi A. Dulac; Jennifer Pizzano; Michael Sinz

doi:10.1124/dmd.109.029637

Research ArticleArticle

Evaluation of Cynomolgus Monkey Pregnane X Receptor, Primary Hepatocyte, and in Vivo Pharmacokinetic Changes in Predicting Human CYP3A4 Induction

Sean Kim, Joseph E. Dinchuk, Monique N. Anthony, Tami Orcutt, Mary E. Zoeckler, Mary B. Sauer, Kathleen W. Mosure, Ragini Vuppugalla, James E. Grace Jr., Jean Simmermacher, Heidi A. Dulac, Jennifer Pizzano and Michael Sinz

Drug Metabolism and Disposition January 2010, 38 (1) 16-24; DOI: https://doi.org/10.1124/dmd.109.029637

Sean Kim

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Joseph E. Dinchuk

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Monique N. Anthony

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Tami Orcutt

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Mary E. Zoeckler

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Mary B. Sauer

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Kathleen W. Mosure

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Ragini Vuppugalla

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James E. Grace Jr.

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Jean Simmermacher

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Heidi A. Dulac

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Jennifer Pizzano

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Michael Sinz

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Drug Metabolism and Disposition

Vol. 38, Issue 1

1 Jan 2010

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Research ArticleArticle

Evaluation of Cynomolgus Monkey Pregnane X Receptor, Primary Hepatocyte, and in Vivo Pharmacokinetic Changes in Predicting Human CYP3A4 Induction

Sean Kim, Joseph E. Dinchuk, Monique N. Anthony, Tami Orcutt, Mary E. Zoeckler, Mary B. Sauer, Kathleen W. Mosure, Ragini Vuppugalla, James E. Grace, Jean Simmermacher, Heidi A. Dulac, Jennifer Pizzano and Michael Sinz

Drug Metabolism and Disposition January 1, 2010, 38 (1) 16-24; DOI: https://doi.org/10.1124/dmd.109.029637

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Research ArticleArticle

Evaluation of Cynomolgus Monkey Pregnane X Receptor, Primary Hepatocyte, and in Vivo Pharmacokinetic Changes in Predicting Human CYP3A4 Induction

Drug Metabolism and Disposition January 1, 2010, 38 (1) 16-24; DOI: https://doi.org/10.1124/dmd.109.029637

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