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Effect of Hepatic Cytochrome P450 (P450) Oxidoreductase Deficiency on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA Adduct Formation in P450 Reductase Conditional Null Mice

Volker M. Arlt, Rajinder Singh, Marie Stiborová, Gonçalo Gamboa da Costa, Eva Frei, James D. Evans, Peter B. Farmer, C. Roland Wolf, Colin J. Henderson and David H. Phillips
Drug Metabolism and Disposition December 2011, 39 (12) 2169-2173; DOI: https://doi.org/10.1124/dmd.111.041343

Article Information

vol. 39 no. 12 2169-2173
DOI 
https://doi.org/10.1124/dmd.111.041343
PubMed 
21940903
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 23, 2011
  • Accepted September 22, 2011
  • Published online November 21, 2011.

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Copyright & Usage 
U.S. Government work not protected by U.S. copyright

Author Information

  1. Volker M. Arlt,
  2. Rajinder Singh,
  3. Marie Stiborová,
  4. Gonçalo Gamboa da Costa,
  5. Eva Frei,
  6. James D. Evans,
  7. Peter B. Farmer,
  8. C. Roland Wolf,
  9. Colin J. Henderson and
  10. David H. Phillips
  1. Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey, United Kingdom (V.M.A., J.D.E., D.H.P.); Cancer Biomarkers and Prevention Group, University of Leicester, Leicester, United Kingdom (R.S., P.B.F.); Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic (M.S.); Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas (G.G.d.C.); Division of Preventive Oncology, National Center for Tumor Diseases, German Cancer Research Center, Heidelberg, Germany (E.F.); and Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Institute, Dundee, United Kingdom (C.R.W., C.J.H.)
  1. Address correspondence to:
    Dr. Volker M. Arlt, Section of Molecular Carcinogenesis, Institute of Cancer Research, Brookes Lawley Building, Sutton, Surrey SM2 5NG, UK. E-mail: volker.arlt{at}icr.ac.uk
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DETECTION OF PhIP-DNA ADDUCTS IN RCN MICE

Volker M. Arlt, Rajinder Singh, Marie Stiborová, Gonçalo Gamboa da Costa, Eva Frei, James D. Evans, Peter B. Farmer, C. Roland Wolf, Colin J. Henderson and David H. Phillips
Drug Metabolism and Disposition December 1, 2011, 39 (12) 2169-2173; DOI: https://doi.org/10.1124/dmd.111.041343
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