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Mechanistic Pharmacokinetic Modeling for the Prediction of Transporter-Mediated Disposition in Humans from Sandwich Culture Human Hepatocyte Data

Hannah M. Jones, Hugh A. Barton, Yurong Lai, Yi-an Bi, Emi Kimoto, Sarah Kempshall, Sonya C. Tate, Ayman El-Kattan, J. Brian Houston, Aleksandra Galetin and Katherine S. Fenner
Drug Metabolism and Disposition May 2012, 40 (5) 1007-1017; DOI: https://doi.org/10.1124/dmd.111.042994

Article Information

vol. 40 no. 5 1007-1017
DOI 
https://doi.org/10.1124/dmd.111.042994
PubMed 
22344703
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 23, 2011
  • Accepted February 16, 2012
  • Published online April 17, 2012.

Article Versions

Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hannah M. Jones1,
  2. Hugh A. Barton,
  3. Yurong Lai,
  4. Yi-an Bi,
  5. Emi Kimoto,
  6. Sarah Kempshall,
  7. Sonya C. Tate,
  8. Ayman El-Kattan,
  9. J. Brian Houston,
  10. Aleksandra Galetin and
  11. Katherine S. Fenner
  1. Pfizer Worldwide R&D, Department of Pharmacokinetics, Dynamics and Metabolism, Sandwich, Kent, United Kingdom (H.M.J., S.K., K.S.F.); Pfizer Worldwide R&D, Department of Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (H.A.B., Y.L., Y.B., E.K., A.E.-K.); and Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom (S.C.T., J.B.H., A.G.)
  1. Address correspondence to:
    Dr. Hannah M. Jones, Pfizer Worldwide R&D, Department of Pharmacokinetics, Dynamics and Metabolism, 35 Cambridgepark Dr., Cambridge, MA 02140. E-mail: hannah.jones{at}pfizer.com

  • ↵1 Current affiliation: Pfizer Worldwide R&D, Department of Pharmacokinetics, Dynamics and Metabolism, Cambridge, Massachusetts.

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PREDICTION OF TRANSPORTER-MEDIATED DISPOSITION IN HUMANS

Hannah M. Jones, Hugh A. Barton, Yurong Lai, Yi-an Bi, Emi Kimoto, Sarah Kempshall, Sonya C. Tate, Ayman El-Kattan, J. Brian Houston, Aleksandra Galetin and Katherine S. Fenner
Drug Metabolism and Disposition May 1, 2012, 40 (5) 1007-1017; DOI: https://doi.org/10.1124/dmd.111.042994
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