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Research ArticleArticle

Boosting of HIV Protease Inhibitors by Ritonavir in the Intestine: The Relative Role of Cytochrome P450 and P-Glycoprotein Inhibition Based on Caco-2 Monolayers versus In Situ Intestinal Perfusion in Mice

Nico Holmstock, Pieter Annaert and Patrick Augustijns
Drug Metabolism and Disposition August 2012, 40 (8) 1473-1477; DOI: https://doi.org/10.1124/dmd.112.044677

Article Information

vol. 40 no. 8 1473-1477
DOI 
https://doi.org/10.1124/dmd.112.044677
PubMed 
22550269
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received January 19, 2012
  • Accepted May 1, 2012
  • Published online July 17, 2012.

Article Versions

Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Nico Holmstock,
  2. Pieter Annaert and
  3. Patrick Augustijns
  1. Laboratory for Pharmacotechnology and Biopharmacy, KU Leuven, Leuven, Belgium
  1. Address correspondence to:
    Patrick Augustijns, Laboratory for Pharmacotechnology and Biopharmacy, KU Leuven, Gasthuisberg O&N 2, Herestraat 49, Box 921-3000, Leuven, Belgium. E-mail: patrick.augustijns{at}pharm.kuleuven.be
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INTESTINAL BOOSTING OF HIV PROTEASE INHIBITORS

Nico Holmstock, Pieter Annaert and Patrick Augustijns
Drug Metabolism and Disposition August 1, 2012, 40 (8) 1473-1477; DOI: https://doi.org/10.1124/dmd.112.044677
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