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Threonine-290 Regulates Nuclear Translocation of the Human Pregnane X Receptor through Its Phosphorylation/Dephosphorylation by Ca2+/Calmodulin-Dependent Protein Kinase II and Protein Phosphatase 1

Junko Sugatani, Yoshiki Hattori, Yuji Noguchi, Masahiko Yamaguchi, Yasuhiro Yamazaki and Akira Ikari
Drug Metabolism and Disposition October 2014, 42 (10) 1708-1718; DOI: https://doi.org/10.1124/dmd.114.059139

Article Information

vol. 42 no. 10 1708-1718
DOI 
https://doi.org/10.1124/dmd.114.059139
PubMed 
25074870
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received May 15, 2014
  • Accepted July 29, 2014
  • Published online September 5, 2014.

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Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Junko Sugatani,
  2. Yoshiki Hattori,
  3. Yuji Noguchi,
  4. Masahiko Yamaguchi,
  5. Yasuhiro Yamazaki, and
  6. Akira Ikari1
  1. Department of Pharmaco-Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
  1. Address correspondence to:
    Dr. Junko Sugatani, Department of Pharmaco-Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. E-mail: sugatani{at}u-shizuoka-ken.ac.jp
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Research ArticleArticle

Threonine-290 Regulates Human PXR Nuclear Translocation

Junko Sugatani, Yoshiki Hattori, Yuji Noguchi, Masahiko Yamaguchi, Yasuhiro Yamazaki and Akira Ikari
Drug Metabolism and Disposition October 1, 2014, 42 (10) 1708-1718; DOI: https://doi.org/10.1124/dmd.114.059139
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