Research ArticleArticle
Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach
Anna Vildhede, André Mateus, Elin K. Khan, Yurong Lai, Maria Karlgren, Per Artursson and Maria C. Kjellsson
Drug Metabolism and Disposition April 2016, 44 (4) 505-516; DOI: https://doi.org/10.1124/dmd.115.066746
Anna Vildhede
Department of Pharmacy (A.V., A.M., E.K.K., M.K., P.A.), Pharmacometrics Research Group, Department of Pharmaceutical Biosciences, Uppsala University (M.C.K.), and Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Chemical Biology Consortium, Science for Life Laboratory (P.A.), Uppsala, Sweden; and Bristol-Myers Squibb, Princeton, New Jersey (Y.L.)
André Mateus
Department of Pharmacy (A.V., A.M., E.K.K., M.K., P.A.), Pharmacometrics Research Group, Department of Pharmaceutical Biosciences, Uppsala University (M.C.K.), and Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Chemical Biology Consortium, Science for Life Laboratory (P.A.), Uppsala, Sweden; and Bristol-Myers Squibb, Princeton, New Jersey (Y.L.)
Elin K. Khan
Department of Pharmacy (A.V., A.M., E.K.K., M.K., P.A.), Pharmacometrics Research Group, Department of Pharmaceutical Biosciences, Uppsala University (M.C.K.), and Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Chemical Biology Consortium, Science for Life Laboratory (P.A.), Uppsala, Sweden; and Bristol-Myers Squibb, Princeton, New Jersey (Y.L.)
Yurong Lai
Department of Pharmacy (A.V., A.M., E.K.K., M.K., P.A.), Pharmacometrics Research Group, Department of Pharmaceutical Biosciences, Uppsala University (M.C.K.), and Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Chemical Biology Consortium, Science for Life Laboratory (P.A.), Uppsala, Sweden; and Bristol-Myers Squibb, Princeton, New Jersey (Y.L.)
Maria Karlgren
Department of Pharmacy (A.V., A.M., E.K.K., M.K., P.A.), Pharmacometrics Research Group, Department of Pharmaceutical Biosciences, Uppsala University (M.C.K.), and Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Chemical Biology Consortium, Science for Life Laboratory (P.A.), Uppsala, Sweden; and Bristol-Myers Squibb, Princeton, New Jersey (Y.L.)
Per Artursson
Department of Pharmacy (A.V., A.M., E.K.K., M.K., P.A.), Pharmacometrics Research Group, Department of Pharmaceutical Biosciences, Uppsala University (M.C.K.), and Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Chemical Biology Consortium, Science for Life Laboratory (P.A.), Uppsala, Sweden; and Bristol-Myers Squibb, Princeton, New Jersey (Y.L.)
Maria C. Kjellsson
Department of Pharmacy (A.V., A.M., E.K.K., M.K., P.A.), Pharmacometrics Research Group, Department of Pharmaceutical Biosciences, Uppsala University (M.C.K.), and Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Chemical Biology Consortium, Science for Life Laboratory (P.A.), Uppsala, Sweden; and Bristol-Myers Squibb, Princeton, New Jersey (Y.L.)
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A Bottom-Up Mechanistic Model for Hepatic Transport
Anna Vildhede, André Mateus, Elin K. Khan, Yurong Lai, Maria Karlgren, Per Artursson and Maria C. Kjellsson
Drug Metabolism and Disposition April 1, 2016, 44 (4) 505-516; DOI: https://doi.org/10.1124/dmd.115.066746
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