Table of Contents

Articles

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  An Assessment of the In Vitro Inhibition of Cytochrome P450 Enzymes, UDP-Glucuronosyltransferases, and Transporters by Phosphodiester- or Phosphorothioate-Linked Oligonucleotides

  Faraz Kazmi, Phyllis Yerino, Chase McCoy, Andrew Parkinson, David B. Buckley and Brian W. Ogilvie

  Drug Metabolism and Disposition August 2018, 46 (8) 1066-1074; DOI: https://doi.org/10.1124/dmd.118.081729
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  Further Studies to Support the Use of Coproporphyrin I and III as Novel Clinical Biomarkers for Evaluating the Potential for Organic Anion Transporting Polypeptide 1B1 and OATP1B3 Inhibition

  Hong Shen, Lisa Christopher, Yurong Lai, Jiachang Gong, Hamza Kandoussi, Samira Garonzik, Vidya Perera, Tushar Garimella and W. Griffith Humphreys

  Drug Metabolism and Disposition August 2018, 46 (8) 1075-1082; DOI: https://doi.org/10.1124/dmd.118.081125
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  Functional Characterization of 21 Allelic Variants of Dihydropyrimidine Dehydrogenase Identified in 1070 Japanese Individuals

  Eiji Hishinuma, Yoko Narita, Sakae Saito, Masamitsu Maekawa, Fumika Akai, Yuya Nakanishi, Jun Yasuda, Masao Nagasaki, Masayuki Yamamoto, Hiroaki Yamaguchi, Nariyasu Mano, Noriyasu Hirasawa and Masahiro Hiratsuka

  Drug Metabolism and Disposition August 2018, 46 (8) 1083-1090; DOI: https://doi.org/10.1124/dmd.118.081737
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  Xanthates: Metabolism by Flavoprotein-Containing Monooxygenases and Antimycobacterial Activity

  Stanislav G. Yanev, Tsveta D. Stoyanova, Violeta V. Valcheva and Paul R. Ortiz de Montellano

  Drug Metabolism and Disposition August 2018, 46 (8) 1091-1095; DOI: https://doi.org/10.1124/dmd.118.081984
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  Multidrug Resistance Protein 1 (MRP1/ABCC1)-Mediated Cellular Protection and Transport of Methylated Arsenic Metabolites Differs between Human Cell Lines

  Mayukh Banerjee, Gurnit Kaur, Brayden D. Whitlock, Michael W. Carew, X. Chris Le and Elaine M. Leslie

  Drug Metabolism and Disposition August 2018, 46 (8) 1096-1105; DOI: https://doi.org/10.1124/dmd.117.079640
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  CYP2D6 Allelic Variants *34, *17-2, *17-3, and *53 and a Thr309Ala Mutant Display Altered Kinetics and NADPH Coupling in Metabolism of Bufuralol and Dextromethorphan and Altered Susceptibility to Inactivation by SCH 66712

  Sarah M. Glass, Cydney M. Martell, Alexandria K. Oswalt, Victoria Osorio-Vasquez, Christi Cho, Michael J. Hicks, Jacqueline M. Mills, Rina Fujiwara, Michael J. Glista, Sharat S. Kamath and Laura Lowe Furge

  Drug Metabolism and Disposition August 2018, 46 (8) 1106-1117; DOI: https://doi.org/10.1124/dmd.117.079871
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  Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1

  Guo Zhong, Margaret O. James, Marci G. Smeltz, Stephan C. Jahn, Taimour Langaee, Pippa Simpson and Peter W. Stacpoole

  Drug Metabolism and Disposition August 2018, 46 (8) 1118-1128; DOI: https://doi.org/10.1124/dmd.118.081810
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  Fluorocholine Transport Mediated by the Organic Cation Transporter 2 (OCT2, SLC22A2): Implication for Imaging of Kidney Tumors

  Michele Visentin, Angelo Torozi, Zhibo Gai, Stephanie Häusler, Chao Li, Christian Hiller, Peter H. Schraml, Holger Moch and Gerd A. Kullak-Ublick

  Drug Metabolism and Disposition August 2018, 46 (8) 1129-1136; DOI: https://doi.org/10.1124/dmd.118.081091
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  Nitidine Chloride Is a Mechanism-Based Inactivator of CYP2D6

  Xu Mao, Zixia Hu, Qian Wang, Na Zhang, Shenzhi Zhou, Ying Peng and Jiang Zheng

  Drug Metabolism and Disposition August 2018, 46 (8) 1137-1145; DOI: https://doi.org/10.1124/dmd.117.079780
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  Regulation of Cytosolic Sulfotransferases in Models of Human Hepatocyte Development

  Sarah Dubaisi, Kathleen G. Barrett, Hailin Fang, Jorge Guzman-Lepe, Alejandro Soto-Gutierrez, Thomas A. Kocarek and Melissa Runge-Morris

  Drug Metabolism and Disposition August 2018, 46 (8) 1146-1156; DOI: https://doi.org/10.1124/dmd.118.081398
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  S-Enantiomer of 19-Hydroxyeicosatetraenoic Acid Preferentially Protects Against Angiotensin II-Induced Cardiac Hypertrophy

  Sherif M. Shoieb and Ayman O. S. El-Kadi

  Drug Metabolism and Disposition August 2018, 46 (8) 1157-1168; DOI: https://doi.org/10.1124/dmd.118.082073
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  Development and Characterization of a Human Hepatocyte Low Intrinsic Clearance Assay for Use in Drug Discovery

  Paul Lancett, Beth Williamson, Patrick Barton and Robert J. Riley

  Drug Metabolism and Disposition August 2018, 46 (8) 1169-1178; DOI: https://doi.org/10.1124/dmd.118.081596
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  Simultaneous Assessment of Transporter-Mediated Drug–Drug Interactions Using a Probe Drug Cocktail in Cynomolgus Monkey

  Rachel E. Kosa, Sarah Lazzaro, Yi-an Bi, Brendan Tierney, Dana Gates, Sweta Modi, Chester Costales, A. David Rodrigues, Larry M. Tremaine and Manthena V. Varma

  Drug Metabolism and Disposition August 2018, 46 (8) 1179-1189; DOI: https://doi.org/10.1124/dmd.118.081794
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  Open Access

  Three Faces of Mercaptopurine Cytotoxicity In Vitro: Methylation, Nucleotide Homeostasis, and Deoxythioguanosine in DNA

  Sally A. Coulthard, Sarah McGarrity, Kalvin Sahota, Philip Berry and Chris P. F. Redfern

  Drug Metabolism and Disposition August 2018, 46 (8) 1191-1199; DOI: https://doi.org/10.1124/dmd.118.081844
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  Application of Physiologically Based Pharmacokinetic Modeling in Understanding Bosutinib Drug-Drug Interactions: Importance of Intestinal P-Glycoprotein

  Shinji Yamazaki, Cho-Ming Loi, Emi Kimoto, Chester Costales and Manthena V. Varma

  Drug Metabolism and Disposition August 2018, 46 (8) 1200-1211; DOI: https://doi.org/10.1124/dmd.118.080424
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  PBDEs Altered Gut Microbiome and Bile Acid Homeostasis in Male C57BL/6 Mice

  Cindy Yanfei Li, Joseph L. Dempsey, Dongfang Wang, SooWan Lee, Kris M. Weigel, Qiang Fei, Deepak Kumar Bhatt, Bhagwat Prasad, Daniel Raftery, Haiwei Gu and Julia Yue Cui

  Drug Metabolism and Disposition August 2018, 46 (8) 1226-1240; DOI: https://doi.org/10.1124/dmd.118.081547
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  Consequences of Phenytoin Exposure on Hepatic Cytochrome P450 Expression during Postnatal Liver Maturation in Mice

  Stephanie C. Piekos, Liming Chen, Pengcheng Wang, Jian Shi, Sharon Yaqoob, Hao-Jie Zhu, Xiaochao Ma and Xiao-bo Zhong

  Drug Metabolism and Disposition August 2018, 46 (8) 1241-1250; DOI: https://doi.org/10.1124/dmd.118.080861