Drug Metabolism and Disposition: 52 (7)

July 01, 2024; Volume 52,Issue 7

Articles

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Survey of Pharmaceutical Industry’s Best Practices around In Vitro Transporter Assessment and Implications for Drug Development: Considerations from the International Consortium for Innovation and Quality for Pharmaceutical Development Transporter Working Group
Helen E. Rollison, Pallabi Mitra, Hugues Chanteux, Zhizhou Fang, Xiaomin Liang, Seong Hee Park, Chester Costales, Imad Hanna, Nilay Thakkar, James M. Vergis, Daniel A.J. Bow, Kathleen M. Hillgren, Jochen Brumm, Xiaoyan Chu, Cornelis E.C.A. Hop, Yurong Lai, Cindy Yanfei Li, Kelly M. Mahar, Laurent Salphati, Rucha Sane, Hong Shen, Kunal Taskar, Mitchell Taub, Kimio Tohyama, Christine Xu and Katherine S. Fenner

Drug Metabolism and Disposition July 2024, 52 (7) 582-596; DOI: https://doi.org/10.1124/dmd.123.001587
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Gut Microbiota Affects Mouse Pregnane X Receptor Agonist Pregnenolone 16α-Carbonitrile-Induced Hepatomegaly by Regulating Pregnane X Receptor and Yes-Associated Protein Activation
Ting Wu, Lu Li, Wenhong Zhou, Guofang Bi, Xiaowen Jiang, Manlan Guo, Xiao Yang, Jianhong Fang, Jianxin Pang, Shicheng Fan and Huichang Bi

Drug Metabolism and Disposition July 2024, 52 (7) 597-605; DOI: https://doi.org/10.1124/dmd.123.001604
Open Access
KLF15-Cyp3a11 Axis Regulates Rifampicin-Induced Liver Injury
Wanqing Hou, Ku-Geng Huo, Xiaohua Guo, Mengtong Xu, Yongting Yang, Zhuangqi Shi, Weixiong Xu, Jinqi Tu, Tangxin Gao, Zhenghai Ma and Shuxin Han

Drug Metabolism and Disposition July 2024, 52 (7) 606-613; DOI: https://doi.org/10.1124/dmd.123.001617
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Physiologically Based Pharmacokinetic Modeling to Predict the Impact of Liver Cirrhosis on Glucuronidation via UGT1A4 and UGT2B7/2B4—A Case Study with Midazolam
Agustos C. Ozbey, Janneke Keemink, Bjoern Wagner, Alessandra Pugliano, Stephan Krähenbühl, Pieter Annaert, Stephen Fowler, Neil Parrott and Kenichi Umehara

Drug Metabolism and Disposition July 2024, 52 (7) 614-625; DOI: https://doi.org/10.1124/dmd.123.001635
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The Role of Intramolecular Reactions and Chemical Degradation in the Apparent Biotransformation Pathways of a Series of SYK Inhibitors
Beatriz Calle, Bernard Barlaam, Coura Diène, Eva Lenz, Scott Martin, Ujjal Sarkar, Stephen Wilkinson and Andy Pike

Drug Metabolism and Disposition July 2024, 52 (7) 626-633; DOI: https://doi.org/10.1124/dmd.124.001659
Open Access
Application of Electro-Activated Dissociation Fragmentation Technique to Identifying Glucuronidation and Oxidative Metabolism Sites of Vepdegestrant by Liquid Chromatography-High Resolution Mass Spectrometry
Yifei He, Pengyi Hou, Zhimin Long, Yuandong Zheng, Chongzhuang Tang, Elliott Jones, Xingxing Diao and Mingshe Zhu

Drug Metabolism and Disposition July 2024, 52 (7) 634-643; DOI: https://doi.org/10.1124/dmd.124.001661
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Xenografted Tumors Share Comparable Fraction Unbound and Can Be Surrogated by Mouse Lung Tissue
Min Wang, Sandip Kuldharan, Aravind Shenoy, Satyanarayana Reddy, Karen Rex, Tao Osgood, Jan Wahlstrom and Upendra P. Dahal

Drug Metabolism and Disposition July 2024, 52 (7) 644-653; DOI: https://doi.org/10.1124/dmd.124.001698
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Pharmacokinetic/Pharmacodynamic Assessment of the Structural Refinement of Clopidogrel Focusing on the Balance between Bioactivation and Deactivation
Dong Sun, Yingze Liu, Lin Zhu, Zhiping Xu, Yuyao Zhang, Haipeng Li, Huan Yang, Xia Cao and Jingkai Gu

Drug Metabolism and Disposition July 2024, 52 (7) 654-661; DOI: https://doi.org/10.1124/dmd.124.001699
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Physiologically Based Pharmacokinetic Modeling: The Reversible Metabolism and Tissue-Specific Partitioning of Methylprednisolone and Methylprednisone in Rats
Ruihong Yu and William J. Jusko

Drug Metabolism and Disposition July 2024, 52 (7) 662-672; DOI: https://doi.org/10.1124/dmd.124.001711
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MALDI Imaging Mass Spectrometry Visualizes the Distribution of Antidepressant Duloxetine and Its Major Metabolites in Mouse Brain, Liver, Kidney, and Spleen Tissues
Saleh M. Khalil, Xuan Qin, John M. Hakenjos, Jian Wang, Zhaoyong Hu, Xinli Liu, Jin Wang, Mirjana Maletic-Savatic, Kevin R. MacKenzie, Martin M. Matzuk and Feng Li

Drug Metabolism and Disposition July 2024, 52 (7) 673-680; DOI: https://doi.org/10.1124/dmd.124.001719
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Tissue-, Region-, and Gene-Specific Induction of Microsomal Epoxide Hydrolase Expression and Activity in the Mouse Intestine by Arsenic in Drinking Water
Hui Li, Xiaoyu Fan, Xinxin Ding and Qing-Yu Zhang

Drug Metabolism and Disposition July 2024, 52 (7) 681-689; DOI: https://doi.org/10.1124/dmd.124.001720
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The Metabolism and Disposition of Brepocitinib in Humans and Characterization of the Formation Mechanism of an Aminopyridine Metabolite
Martin E. Dowty, Ruolun Qiu, Alyssa Dantonio, Mark Niosi, Angela Doran, Amanda Balesano, Stephen W. Wright, Gregory S. Walker and Raman Sharma

Drug Metabolism and Disposition July 2024, 52 (7) 690-702; DOI: https://doi.org/10.1124/dmd.124.001750