Research ArticleArticle
Tariquidar and Elacridar Are Dose-Dependently Transported by P-Glycoprotein and Bcrp at the Blood-Brain Barrier: A Small-Animal Positron Emission Tomography and In Vitro Study
Jens P. Bankstahl, Marion Bankstahl, Kerstin Römermann, Thomas Wanek, Johann Stanek, Albert D. Windhorst, Maren Fedrowitz, Thomas Erker, Markus Müller, Wolfgang Löscher, Oliver Langer and Claudia Kuntner
Drug Metabolism and Disposition April 2013, 41 (4) 754-762; DOI: https://doi.org/10.1124/dmd.112.049148
Jens P. Bankstahl
Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, and Center for Systems Neuroscience, Hannover, Germany (J.P.B., M.B., K.R., M.F., W.L.); Department of Nuclear Medicine, Preclinical Molecular Imaging, Hannover Medical School, Hannover, Germany (J.P.B.); Health and Environment Department, Biomedical Systems, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria (T.W., J.S., O.L., C.K.); Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria (J.S., M.M., O.L.); Department of Medicinal Chemistry, University of Vienna, Vienna, Austria (T.E.); and Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands (A.D.W.)
Marion Bankstahl
Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, and Center for Systems Neuroscience, Hannover, Germany (J.P.B., M.B., K.R., M.F., W.L.); Department of Nuclear Medicine, Preclinical Molecular Imaging, Hannover Medical School, Hannover, Germany (J.P.B.); Health and Environment Department, Biomedical Systems, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria (T.W., J.S., O.L., C.K.); Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria (J.S., M.M., O.L.); Department of Medicinal Chemistry, University of Vienna, Vienna, Austria (T.E.); and Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands (A.D.W.)
Kerstin Römermann
Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, and Center for Systems Neuroscience, Hannover, Germany (J.P.B., M.B., K.R., M.F., W.L.); Department of Nuclear Medicine, Preclinical Molecular Imaging, Hannover Medical School, Hannover, Germany (J.P.B.); Health and Environment Department, Biomedical Systems, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria (T.W., J.S., O.L., C.K.); Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria (J.S., M.M., O.L.); Department of Medicinal Chemistry, University of Vienna, Vienna, Austria (T.E.); and Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands (A.D.W.)
Thomas Wanek
Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, and Center for Systems Neuroscience, Hannover, Germany (J.P.B., M.B., K.R., M.F., W.L.); Department of Nuclear Medicine, Preclinical Molecular Imaging, Hannover Medical School, Hannover, Germany (J.P.B.); Health and Environment Department, Biomedical Systems, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria (T.W., J.S., O.L., C.K.); Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria (J.S., M.M., O.L.); Department of Medicinal Chemistry, University of Vienna, Vienna, Austria (T.E.); and Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands (A.D.W.)
Johann Stanek
Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, and Center for Systems Neuroscience, Hannover, Germany (J.P.B., M.B., K.R., M.F., W.L.); Department of Nuclear Medicine, Preclinical Molecular Imaging, Hannover Medical School, Hannover, Germany (J.P.B.); Health and Environment Department, Biomedical Systems, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria (T.W., J.S., O.L., C.K.); Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria (J.S., M.M., O.L.); Department of Medicinal Chemistry, University of Vienna, Vienna, Austria (T.E.); and Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands (A.D.W.)
Albert D. Windhorst
Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, and Center for Systems Neuroscience, Hannover, Germany (J.P.B., M.B., K.R., M.F., W.L.); Department of Nuclear Medicine, Preclinical Molecular Imaging, Hannover Medical School, Hannover, Germany (J.P.B.); Health and Environment Department, Biomedical Systems, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria (T.W., J.S., O.L., C.K.); Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria (J.S., M.M., O.L.); Department of Medicinal Chemistry, University of Vienna, Vienna, Austria (T.E.); and Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands (A.D.W.)
Maren Fedrowitz
Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, and Center for Systems Neuroscience, Hannover, Germany (J.P.B., M.B., K.R., M.F., W.L.); Department of Nuclear Medicine, Preclinical Molecular Imaging, Hannover Medical School, Hannover, Germany (J.P.B.); Health and Environment Department, Biomedical Systems, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria (T.W., J.S., O.L., C.K.); Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria (J.S., M.M., O.L.); Department of Medicinal Chemistry, University of Vienna, Vienna, Austria (T.E.); and Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands (A.D.W.)
Thomas Erker
Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, and Center for Systems Neuroscience, Hannover, Germany (J.P.B., M.B., K.R., M.F., W.L.); Department of Nuclear Medicine, Preclinical Molecular Imaging, Hannover Medical School, Hannover, Germany (J.P.B.); Health and Environment Department, Biomedical Systems, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria (T.W., J.S., O.L., C.K.); Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria (J.S., M.M., O.L.); Department of Medicinal Chemistry, University of Vienna, Vienna, Austria (T.E.); and Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands (A.D.W.)
Markus Müller
Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, and Center for Systems Neuroscience, Hannover, Germany (J.P.B., M.B., K.R., M.F., W.L.); Department of Nuclear Medicine, Preclinical Molecular Imaging, Hannover Medical School, Hannover, Germany (J.P.B.); Health and Environment Department, Biomedical Systems, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria (T.W., J.S., O.L., C.K.); Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria (J.S., M.M., O.L.); Department of Medicinal Chemistry, University of Vienna, Vienna, Austria (T.E.); and Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands (A.D.W.)
Wolfgang Löscher
Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, and Center for Systems Neuroscience, Hannover, Germany (J.P.B., M.B., K.R., M.F., W.L.); Department of Nuclear Medicine, Preclinical Molecular Imaging, Hannover Medical School, Hannover, Germany (J.P.B.); Health and Environment Department, Biomedical Systems, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria (T.W., J.S., O.L., C.K.); Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria (J.S., M.M., O.L.); Department of Medicinal Chemistry, University of Vienna, Vienna, Austria (T.E.); and Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands (A.D.W.)
Oliver Langer
Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, and Center for Systems Neuroscience, Hannover, Germany (J.P.B., M.B., K.R., M.F., W.L.); Department of Nuclear Medicine, Preclinical Molecular Imaging, Hannover Medical School, Hannover, Germany (J.P.B.); Health and Environment Department, Biomedical Systems, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria (T.W., J.S., O.L., C.K.); Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria (J.S., M.M., O.L.); Department of Medicinal Chemistry, University of Vienna, Vienna, Austria (T.E.); and Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands (A.D.W.)
Claudia Kuntner
Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, and Center for Systems Neuroscience, Hannover, Germany (J.P.B., M.B., K.R., M.F., W.L.); Department of Nuclear Medicine, Preclinical Molecular Imaging, Hannover Medical School, Hannover, Germany (J.P.B.); Health and Environment Department, Biomedical Systems, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria (T.W., J.S., O.L., C.K.); Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria (J.S., M.M., O.L.); Department of Medicinal Chemistry, University of Vienna, Vienna, Austria (T.E.); and Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands (A.D.W.)
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Research ArticleArticle
Transport of Tariquidar and Elacridar by Pgp and Bcrp
Jens P. Bankstahl, Marion Bankstahl, Kerstin Römermann, Thomas Wanek, Johann Stanek, Albert D. Windhorst, Maren Fedrowitz, Thomas Erker, Markus Müller, Wolfgang Löscher, Oliver Langer and Claudia Kuntner
Drug Metabolism and Disposition April 1, 2013, 41 (4) 754-762; DOI: https://doi.org/10.1124/dmd.112.049148
Research ArticleArticle
Transport of Tariquidar and Elacridar by Pgp and Bcrp
Jens P. Bankstahl, Marion Bankstahl, Kerstin Römermann, Thomas Wanek, Johann Stanek, Albert D. Windhorst, Maren Fedrowitz, Thomas Erker, Markus Müller, Wolfgang Löscher, Oliver Langer and Claudia Kuntner
Drug Metabolism and Disposition April 1, 2013, 41 (4) 754-762; DOI: https://doi.org/10.1124/dmd.112.049148
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