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Research ArticleArticle

BIOACTIVATION OF THE NONTRICYCLIC ANTIDEPRESSANT NEFAZODONE TO A REACTIVE QUINONE-IMINE SPECIES IN HUMAN LIVER MICROSOMES AND RECOMBINANT CYTOCHROME P450 3A4

Amit S. Kalgutkar, Alfin D. N. Vaz, Mary E. Lame, Kirk R. Henne, John Soglia, Sabrina X. Zhao, Yuri A. Abramov, Franco Lombardo, Claire Collin, Zachary S. Hendsch and Cornelis E. C. A. Hop
Drug Metabolism and Disposition February 2005, 33 (2) 243-253; DOI: https://doi.org/10.1124/dmd.104.001735

Article Information

vol. 33 no. 2 243-253
DOI 
https://doi.org/10.1124/dmd.104.001735
PubMed 
15523046
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 3, 2004
  • Accepted October 28, 2004
  • Published online January 19, 2005.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Amit S. Kalgutkar,
  2. Alfin D. N. Vaz,
  3. Mary E. Lame,
  4. Kirk R. Henne,
  5. John Soglia,
  6. Sabrina X. Zhao,
  7. Yuri A. Abramov,
  8. Franco Lombardo,
  9. Claire Collin,
  10. Zachary S. Hendsch and
  11. Cornelis E. C. A. Hop
  1. Pharmacokinetics, Dynamics and Metabolism Department (A.S.K., A.D.N.V., M.E.L., K.R.H., J.S., S.X.Z., C.C., C.E.C.A.H.), and Leads Progression Group (Y.A.A., F.L., Z.S.H.), Pfizer Global Research and Development, Groton, Connecticut
  1. Address correspondence to:
    Amit S. Kalgutkar, Pharmacokinetics, Dynamics, and Metabolism Department, Pfizer Global Research and Development, Groton, CT 06340. E-mail: amit_kalgutkar{at}groton.pfizer.com
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Research ArticleArticle

BIOACTIVATION OF THE NONTRICYCLIC ANTIDEPRESSANT NEFAZODONE TO A REACTIVE QUINONE-IMINE SPECIES IN HUMAN LIVER MICROSOMES AND RECOMBINANT CYTOCHROME P450 3A4

Amit S. Kalgutkar, Alfin D. N. Vaz, Mary E. Lame, Kirk R. Henne, John Soglia, Sabrina X. Zhao, Yuri A. Abramov, Franco Lombardo, Claire Collin, Zachary S. Hendsch and Cornelis E. C. A. Hop
Drug Metabolism and Disposition February 1, 2005, 33 (2) 243-253; DOI: https://doi.org/10.1124/dmd.104.001735
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