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Evaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free Concentration

Xingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffrey Van Deusen
Drug Metabolism and Disposition September 2006, 34 (9) 1443-1447; DOI: https://doi.org/10.1124/dmd.105.008201

Article Information

vol. 34 no. 9 1443-1447
DOI 
https://doi.org/10.1124/dmd.105.008201
PubMed 
16760229
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 4, 2005
  • Accepted May 23, 2006
  • Published online August 22, 2006.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Xingrong Liu,
  2. Bill J. Smith,
  3. Cuiping Chen,
  4. Ernesto Callegari,
  5. Stacey L. Becker,
  6. Xi Chen,
  7. Julie Cianfrogna,
  8. Angela C. Doran,
  9. Shawn D. Doran,
  10. John P. Gibbs,
  11. Natilie Hosea,
  12. Jianhua Liu,
  13. Frederick R. Nelson,
  14. Mark A. Szewc and
  15. Jeffrey Van Deusen
  1. Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Groton, Connecticut
  1. Address correspondence to:
    Dr. Xingrong Liu, Drug Metabolism and Pharmacokinetics, Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, CA 94304. E-mail: xingrong.liu{at}roche.com
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OtherShort Communication

Evaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free Concentration

Xingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc and Jeffrey Van Deusen
Drug Metabolism and Disposition September 1, 2006, 34 (9) 1443-1447; DOI: https://doi.org/10.1124/dmd.105.008201
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