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Research ArticleArticle

Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes

Seigo Sanoh, Kazuyoshi Nozaki, Hidetsugu Murai, Shigeyuki Terashita, Toshio Teramura and Shigeru Ohta
Drug Metabolism and Disposition January 2012, 40 (1) 76-82; DOI: https://doi.org/10.1124/dmd.111.041954

Article Information

vol. 40 no. 1 76-82
DOI 
https://doi.org/10.1124/dmd.111.041954
PubMed 
21984595
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 5, 2011
  • Accepted October 7, 2011
  • Published online December 16, 2011.

Article Versions

Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Seigo Sanoh,
  2. Kazuyoshi Nozaki,
  3. Hidetsugu Murai,
  4. Shigeyuki Terashita,
  5. Toshio Teramura and
  6. Shigeru Ohta
  1. Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan (S.S., S.O.); and Analysis and Pharmacokinetics Research Laboratories, Astellas Pharma Inc., Ibaraki, Japan (K.N., H.M., S.T., T.T.)
  1. Address correspondence to:
    Seigo Sanoh, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8553 Japan. E-mail: sanoh{at}hiroshima-u.ac.jp
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METABOLISM BY ALDEHYDE OXIDASE IN HUMAN LIVER CHIMERIC MICE

Seigo Sanoh, Kazuyoshi Nozaki, Hidetsugu Murai, Shigeyuki Terashita, Toshio Teramura and Shigeru Ohta
Drug Metabolism and Disposition January 1, 2012, 40 (1) 76-82; DOI: https://doi.org/10.1124/dmd.111.041954
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