Research ArticleArticle
Use of Mechanistic Modeling to Assess Interindividual Variability and Interspecies Differences in Active Uptake in Human and Rat Hepatocytes
Karelle Ménochet, Kathryn E. Kenworthy, J. Brian Houston and Aleksandra Galetin
Drug Metabolism and Disposition September 2012, 40 (9) 1744-1756; DOI: https://doi.org/10.1124/dmd.112.046193
Karelle Ménochet
Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom (K.M., J.B.H., A.G.); and Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (K.E.K.)
Kathryn E. Kenworthy
Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom (K.M., J.B.H., A.G.); and Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (K.E.K.)
J. Brian Houston
Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom (K.M., J.B.H., A.G.); and Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (K.E.K.)
Aleksandra Galetin
Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom (K.M., J.B.H., A.G.); and Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom (K.E.K.)
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MODELING OF HEPATIC UPTAKE IN HUMAN HEPATOCYTES
Karelle Ménochet, Kathryn E. Kenworthy, J. Brian Houston and Aleksandra Galetin
Drug Metabolism and Disposition September 1, 2012, 40 (9) 1744-1756; DOI: https://doi.org/10.1124/dmd.112.046193
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