Advertisement
Research ArticleSpecial Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems

Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac

Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald Tweedie
Drug Metabolism and Disposition December 2013, 41 (12) 2024-2032; DOI: https://doi.org/10.1124/dmd.113.053397

Article Information

vol. 41 no. 12 2024-2032
DOI 
https://doi.org/10.1124/dmd.113.053397
PubMed 
23959596
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 20, 2013
  • Accepted August 15, 2013
  • Published online November 14, 2013.

Article Versions

Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Tom S. Chan,
  2. Hongbin Yu,
  3. Amanda Moore,
  4. Salman R. Khetani, and
  5. Donald Tweedie
  1. Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut (T.S.C., H.Y., D.T.); Hepregen Corporation, Medford, Massachusetts (A.M.); and Mechanical and Biomedical Engineering, Colorado State University, Fort Collins, Colorado (S.R.K.)
  1. Address correspondence to:
    Hongbin Yu, Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Rd., Ridgefield, CT 06877. E-mail: hongbin.yu{at}boehringer-ingelheim.com
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: August 2017 to December 2024

AbstractFullPdf
Aug 201754122
Sep 201744316
Oct 201766132
Nov 201746030
Dec 201714113
Jan 201855628
Feb 201865723
Mar 201816337
Apr 201815026
May 201865736
Jun 201856324
Jul 201847939
Aug 201823722
Sep 201843019
Oct 201845520
Nov 201856635
Dec 2018553719
Jan 2019741326
Feb 2019321718
Mar 201952311
Apr 201944618
May 20194059
Jun 2019107313
Jul 20191681115
Aug 2019103413
Oct 2019471110
Nov 2019422134
Dec 2019683326
Jan 202049118
Feb 20202968
Mar 2020511113
May 20205288
Jun 20201256
Jul 20203133
Aug 20202135
Sep 202060215
Oct 202068389
Nov 2020361516
Dec 202027127
Jan 2021874034
Feb 2021342812
Mar 2021461615
Apr 2021461710
May 20216484
Jun 202154123
Jul 202122108
Aug 202137309
Sep 202131116
Oct 2021461510
Nov 2021441710
Dec 20212952
Jan 20225882
Feb 20227093
Mar 202237156
Apr 202241169
May 202247108
Jun 2022581810
Jul 2022551319
Aug 202270207
Sep 202248246
Oct 202242319
Nov 2022201511
Dec 202226410
Jan 202388205
Feb 20236157
Mar 202393126
Apr 2023401011
May 202342246
Jun 202343134
Jul 202333165
Aug 202344264
Sep 2023671020
Oct 202375911
Nov 2023881210
Dec 20232064717
Jan 20241111416
Feb 202483308
Mar 202482910
Apr 202469134
May 2024154425
Jun 2024713311
Jul 2024703318
Aug 202473189
Sep 2024773720
Oct 202445116
Nov 20243152
Dec 20242484

Back to top

In this issue

Download PDF
Article Alerts
Email Article
Citation Tools

Research ArticleSpecial Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems

Clearance Prediction Using HepatoPac

Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald Tweedie
Drug Metabolism and Disposition December 1, 2013, 41 (12) 2024-2032; DOI: https://doi.org/10.1124/dmd.113.053397
Twitter logo Facebook logo Mendeley logo

Jump to section

Advertisement