Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac

Tom S. Chan; Hongbin Yu; Amanda Moore; Salman R. Khetani; Donald Tweedie

doi:10.1124/dmd.113.053397

Research ArticleSpecial Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems

Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac

Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald Tweedie

Drug Metabolism and Disposition December 2013, 41 (12) 2024-2032; DOI: https://doi.org/10.1124/dmd.113.053397

Tom S. Chan

Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut (T.S.C., H.Y., D.T.); Hepregen Corporation, Medford, Massachusetts (A.M.); and Mechanical and Biomedical Engineering, Colorado State University, Fort Collins, Colorado (S.R.K.)

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Hongbin Yu

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Amanda Moore

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Salman R. Khetani

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Donald Tweedie

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Drug Metabolism and Disposition

Vol. 41, Issue 12

1 Dec 2013

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Research ArticleSpecial Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems