Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac

Tom S. Chan; Hongbin Yu; Amanda Moore; Salman R. Khetani; Donald Tweedie

doi:10.1124/dmd.113.053397

Research ArticleSpecial Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems

Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac

Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald Tweedie

Drug Metabolism and Disposition December 2013, 41 (12) 2024-2032; DOI: https://doi.org/10.1124/dmd.113.053397

Tom S. Chan

Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut (T.S.C., H.Y., D.T.); Hepregen Corporation, Medford, Massachusetts (A.M.); and Mechanical and Biomedical Engineering, Colorado State University, Fort Collins, Colorado (S.R.K.)

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Hongbin Yu

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Amanda Moore

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Salman R. Khetani

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Donald Tweedie

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Drug Metabolism and Disposition

Vol. 41, Issue 12

1 Dec 2013

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Research ArticleSpecial Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems

Clearance Prediction Using HepatoPac

Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald Tweedie

Drug Metabolism and Disposition December 1, 2013, 41 (12) 2024-2032; DOI: https://doi.org/10.1124/dmd.113.053397

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Research ArticleSpecial Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems

Clearance Prediction Using HepatoPac

Tom S. Chan, Hongbin Yu, Amanda Moore, Salman R. Khetani and Donald Tweedie

Drug Metabolism and Disposition December 1, 2013, 41 (12) 2024-2032; DOI: https://doi.org/10.1124/dmd.113.053397

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