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Pharmacoproteomics-Based Reconstruction of In Vivo P-Glycoprotein Function at Blood-Brain Barrier and Brain Distribution of Substrate Verapamil in Pentylenetetrazole-Kindled Epilepsy, Spontaneous Epilepsy, and Phenytoin Treatment Models

Yasuo Uchida, Sumio Ohtsuki and Tetsuya Terasaki
Drug Metabolism and Disposition October 2014, 42 (10) 1719-1726; DOI: https://doi.org/10.1124/dmd.114.059055

Article Information

vol. 42 no. 10 1719-1726
DOI 
https://doi.org/10.1124/dmd.114.059055
PubMed 
25061162
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received May 13, 2014
  • Accepted July 24, 2014
  • Published online September 5, 2014.

Article Versions

Copyright & Usage 
Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yasuo Uchida,
  2. Sumio Ohtsuki, and
  3. Tetsuya Terasaki
  1. Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan (Y.U., T.T.); and Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan (S.O.)
  1. Address correspondence to:
    Dr. Tetsuya Terasaki, Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, 980-8578, Japan. E-mail: terasaki.tetsuya{at}m.tohoku.ac.jp
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Prediction of BBB P-gp Efflux in Epilepsy and Treatment

Yasuo Uchida, Sumio Ohtsuki and Tetsuya Terasaki
Drug Metabolism and Disposition October 1, 2014, 42 (10) 1719-1726; DOI: https://doi.org/10.1124/dmd.114.059055
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