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Amlodipine Metabolism in Human Liver Microsomes and Roles of CYP3A4/5 in the Dihydropyridine Dehydrogenation

Yanlin Zhu, Fen Wang, Quan Li, Mingshe Zhu, Alicia Du, Wei Tang and Weiqing Chen
Drug Metabolism and Disposition February 2014, 42 (2) 245-249; DOI: https://doi.org/10.1124/dmd.113.055400

Article Information

vol. 42 no. 2 245-249
DOI 
https://doi.org/10.1124/dmd.113.055400
PubMed 
24301608
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 15, 2013
  • Accepted December 3, 2013
  • Published online December 31, 2013.

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Copyright & Usage 
Copyright © 2013 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yanlin Zhu,
  2. Fen Wang,
  3. Quan Li,
  4. Mingshe Zhu,
  5. Alicia Du,
  6. Wei Tang, and
  7. Weiqing Chen
  1. DMPK Department, Shanghai ChemPartner, Shanghai, People’s Republic of China (Y.Z., F.W., Q.L., A.D., W.T., W.C.) and Department of Biotransformation, Bristol-Myers Squibb, Princeton, New Jersey (M.Z.)
  1. Address correspondence to:
    Weiqing Chen, DMPK Department, Shanghai ChemPartner, 998 Halei Rd., Zhangjiang Hi-tech PK, Pudong New Area, Shanghai 201203, PR China. E-mail: weiqingchen{at}chempartner.cn or Mingshe Zhu, Biotransformation Department, Bristol-Myers Squibb, Princeton, NJ 08543. E-mail: mingshe.zhu{at}bms.com
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Rapid CommunicationShort Communication

Metabolism of Amlodipine by HLM and CYP3A4

Yanlin Zhu, Fen Wang, Quan Li, Mingshe Zhu, Alicia Du, Wei Tang and Weiqing Chen
Drug Metabolism and Disposition February 1, 2014, 42 (2) 245-249; DOI: https://doi.org/10.1124/dmd.113.055400
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