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Research ArticleArticle

Rosuvastatin Liver Partitioning in Cynomolgus Monkeys: Measurement In Vivo and Prediction Using In Vitro Monkey Hepatocyte Uptake

Bridget L. Morse, Hong Cai, Jamus G. MacGuire, Maxine Fox, Lisa Zhang, Yueping Zhang, Xiaomei Gu, Hong Shen, Elizabeth A. Dierks, Hong Su, Chiuwa E. Luk, Punit Marathe, Yue-Zhong Shu, W. Griffith Humphreys and Yurong Lai
Drug Metabolism and Disposition November 2015, 43 (11) 1788-1794; DOI: https://doi.org/10.1124/dmd.115.065946

Article Information

vol. 43 no. 11 1788-1794
DOI 
https://doi.org/10.1124/dmd.115.065946
PubMed 
26341276
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 11, 2015
  • Accepted September 3, 2015
  • Published online October 12, 2015.

Article Versions

Copyright & Usage 
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Bridget L. Morse,
  2. Hong Cai1,
  3. Jamus G. MacGuire,
  4. Maxine Fox,
  5. Lisa Zhang,
  6. Yueping Zhang,
  7. Xiaomei Gu,
  8. Hong Shen,
  9. Elizabeth A. Dierks,
  10. Hong Su,
  11. Chiuwa E. Luk,
  12. Punit Marathe,
  13. Yue-Zhong Shu,
  14. W. Griffith Humphreys, and
  15. Yurong Lai
  1. Pharmaceutical Candidate Optimization (B.L.M., H.C., L.Z., Y.Z., X.G., H.S., E.A.D., H.S., C.E.L., P.M., Y-Z.S., W.G.H., Y.L.) and Veterinary Sciences, Bristol-Myers Squibb, Princeton, New Jersey (J.G.M., M.F.)
  1. Address correspondence to:
    Yurong Lai, Route 206 and Provinceline Rd, Princeton, NJ 08540. E-mail: yurong.lai{at}bms.com
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Prediction of Rosuvastatin Liver Partitioning in Monkeys

Bridget L. Morse, Hong Cai, Jamus G. MacGuire, Maxine Fox, Lisa Zhang, Yueping Zhang, Xiaomei Gu, Hong Shen, Elizabeth A. Dierks, Hong Su, Chiuwa E. Luk, Punit Marathe, Yue-Zhong Shu, W. Griffith Humphreys and Yurong Lai
Drug Metabolism and Disposition November 1, 2015, 43 (11) 1788-1794; DOI: https://doi.org/10.1124/dmd.115.065946
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