Research ArticleArticle
Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice with Humanized Livers
Hidetaka Kamimura, Satoshi Ito, Kohei Nozawa, Shota Nakamura, Hiroyuki Chijiwa, Shin-ichiro Nagatsuka, Miyuki Kuronuma, Yasuyuki Ohnishi, Hiroshi Suemizu and Shin-ichi Ninomiya
Drug Metabolism and Disposition March 2015, 43 (3) 309-316; DOI: https://doi.org/10.1124/dmd.114.061689
Hidetaka Kamimura
ADME & Tox. Research Institute, Sekisui Medical Co., Ltd., Tokyo, Japan (H.K., S.I., K.N., S.Nak., H.C., S.Nag., S.Ni); and Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan (M.K., Y.O., H.S.)
Satoshi Ito
ADME & Tox. Research Institute, Sekisui Medical Co., Ltd., Tokyo, Japan (H.K., S.I., K.N., S.Nak., H.C., S.Nag., S.Ni); and Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan (M.K., Y.O., H.S.)
Kohei Nozawa
ADME & Tox. Research Institute, Sekisui Medical Co., Ltd., Tokyo, Japan (H.K., S.I., K.N., S.Nak., H.C., S.Nag., S.Ni); and Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan (M.K., Y.O., H.S.)
Shota Nakamura
ADME & Tox. Research Institute, Sekisui Medical Co., Ltd., Tokyo, Japan (H.K., S.I., K.N., S.Nak., H.C., S.Nag., S.Ni); and Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan (M.K., Y.O., H.S.)
Hiroyuki Chijiwa
ADME & Tox. Research Institute, Sekisui Medical Co., Ltd., Tokyo, Japan (H.K., S.I., K.N., S.Nak., H.C., S.Nag., S.Ni); and Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan (M.K., Y.O., H.S.)
Shin-ichiro Nagatsuka
ADME & Tox. Research Institute, Sekisui Medical Co., Ltd., Tokyo, Japan (H.K., S.I., K.N., S.Nak., H.C., S.Nag., S.Ni); and Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan (M.K., Y.O., H.S.)
Miyuki Kuronuma
ADME & Tox. Research Institute, Sekisui Medical Co., Ltd., Tokyo, Japan (H.K., S.I., K.N., S.Nak., H.C., S.Nag., S.Ni); and Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan (M.K., Y.O., H.S.)
Yasuyuki Ohnishi
ADME & Tox. Research Institute, Sekisui Medical Co., Ltd., Tokyo, Japan (H.K., S.I., K.N., S.Nak., H.C., S.Nag., S.Ni); and Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan (M.K., Y.O., H.S.)
Hiroshi Suemizu
ADME & Tox. Research Institute, Sekisui Medical Co., Ltd., Tokyo, Japan (H.K., S.I., K.N., S.Nak., H.C., S.Nag., S.Ni); and Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan (M.K., Y.O., H.S.)
Shin-ichi Ninomiya
ADME & Tox. Research Institute, Sekisui Medical Co., Ltd., Tokyo, Japan (H.K., S.I., K.N., S.Nak., H.C., S.Nag., S.Ni); and Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan (M.K., Y.O., H.S.)
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In this issue
Research ArticleArticle
Metabolism of Diclofenac in Humanized TK-NOG Chimeric Mice
Hidetaka Kamimura, Satoshi Ito, Kohei Nozawa, Shota Nakamura, Hiroyuki Chijiwa, Shin-ichiro Nagatsuka, Miyuki Kuronuma, Yasuyuki Ohnishi, Hiroshi Suemizu and Shin-ichi Ninomiya
Drug Metabolism and Disposition March 1, 2015, 43 (3) 309-316; DOI: https://doi.org/10.1124/dmd.114.061689
Research ArticleArticle
Metabolism of Diclofenac in Humanized TK-NOG Chimeric Mice
Hidetaka Kamimura, Satoshi Ito, Kohei Nozawa, Shota Nakamura, Hiroyuki Chijiwa, Shin-ichiro Nagatsuka, Miyuki Kuronuma, Yasuyuki Ohnishi, Hiroshi Suemizu and Shin-ichi Ninomiya
Drug Metabolism and Disposition March 1, 2015, 43 (3) 309-316; DOI: https://doi.org/10.1124/dmd.114.061689
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