Research ArticleArticle
In Vitro and In Vivo Characterization of 13 CYP2C9 Allelic Variants Found in Chinese Han Population
Guo-Xin Hu, Pei-Pei Pan, Zeng-Shou Wang, Li-Ping Yang, Da-Peng Dai, Shuang-Hu Wang, Guang-Hui Zhu, Xiang-Jun Qiu, Tao Xu, Jun Luo, Qing-Quan Lian, Ren-Shan Ge and Jian-Ping Cai
Drug Metabolism and Disposition April 2015, 43 (4) 561-569; DOI: https://doi.org/10.1124/dmd.114.061200
Guo-Xin Hu
Testing and Analysis Laboratory for Phase I Clinical Trials (G.-X.H., P.-P.P., S.-H.W., T.X., J.L.) and Second Affiliated Hospital and Yuying Children's Hospital (Z.-S.W., G.-H.Z., Q.-Q.L., R.-S.G.), Wenzhou Medical University, Wenzhou, P.R. China; Department of Pharmacy, Beijing Hospital, Ministry of Health, Beijing, P.R. China (L.-P.Y.); Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, P.R. China (D.-P.D., J.-P.C.); and Medical College of Henan University of Science and Technology, Luoyang, P.R. China (X.-J.Q.)
Pei-Pei Pan
Testing and Analysis Laboratory for Phase I Clinical Trials (G.-X.H., P.-P.P., S.-H.W., T.X., J.L.) and Second Affiliated Hospital and Yuying Children's Hospital (Z.-S.W., G.-H.Z., Q.-Q.L., R.-S.G.), Wenzhou Medical University, Wenzhou, P.R. China; Department of Pharmacy, Beijing Hospital, Ministry of Health, Beijing, P.R. China (L.-P.Y.); Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, P.R. China (D.-P.D., J.-P.C.); and Medical College of Henan University of Science and Technology, Luoyang, P.R. China (X.-J.Q.)
Zeng-Shou Wang
Testing and Analysis Laboratory for Phase I Clinical Trials (G.-X.H., P.-P.P., S.-H.W., T.X., J.L.) and Second Affiliated Hospital and Yuying Children's Hospital (Z.-S.W., G.-H.Z., Q.-Q.L., R.-S.G.), Wenzhou Medical University, Wenzhou, P.R. China; Department of Pharmacy, Beijing Hospital, Ministry of Health, Beijing, P.R. China (L.-P.Y.); Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, P.R. China (D.-P.D., J.-P.C.); and Medical College of Henan University of Science and Technology, Luoyang, P.R. China (X.-J.Q.)
Li-Ping Yang
Testing and Analysis Laboratory for Phase I Clinical Trials (G.-X.H., P.-P.P., S.-H.W., T.X., J.L.) and Second Affiliated Hospital and Yuying Children's Hospital (Z.-S.W., G.-H.Z., Q.-Q.L., R.-S.G.), Wenzhou Medical University, Wenzhou, P.R. China; Department of Pharmacy, Beijing Hospital, Ministry of Health, Beijing, P.R. China (L.-P.Y.); Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, P.R. China (D.-P.D., J.-P.C.); and Medical College of Henan University of Science and Technology, Luoyang, P.R. China (X.-J.Q.)
Da-Peng Dai
Testing and Analysis Laboratory for Phase I Clinical Trials (G.-X.H., P.-P.P., S.-H.W., T.X., J.L.) and Second Affiliated Hospital and Yuying Children's Hospital (Z.-S.W., G.-H.Z., Q.-Q.L., R.-S.G.), Wenzhou Medical University, Wenzhou, P.R. China; Department of Pharmacy, Beijing Hospital, Ministry of Health, Beijing, P.R. China (L.-P.Y.); Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, P.R. China (D.-P.D., J.-P.C.); and Medical College of Henan University of Science and Technology, Luoyang, P.R. China (X.-J.Q.)
Shuang-Hu Wang
Testing and Analysis Laboratory for Phase I Clinical Trials (G.-X.H., P.-P.P., S.-H.W., T.X., J.L.) and Second Affiliated Hospital and Yuying Children's Hospital (Z.-S.W., G.-H.Z., Q.-Q.L., R.-S.G.), Wenzhou Medical University, Wenzhou, P.R. China; Department of Pharmacy, Beijing Hospital, Ministry of Health, Beijing, P.R. China (L.-P.Y.); Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, P.R. China (D.-P.D., J.-P.C.); and Medical College of Henan University of Science and Technology, Luoyang, P.R. China (X.-J.Q.)
Guang-Hui Zhu
Testing and Analysis Laboratory for Phase I Clinical Trials (G.-X.H., P.-P.P., S.-H.W., T.X., J.L.) and Second Affiliated Hospital and Yuying Children's Hospital (Z.-S.W., G.-H.Z., Q.-Q.L., R.-S.G.), Wenzhou Medical University, Wenzhou, P.R. China; Department of Pharmacy, Beijing Hospital, Ministry of Health, Beijing, P.R. China (L.-P.Y.); Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, P.R. China (D.-P.D., J.-P.C.); and Medical College of Henan University of Science and Technology, Luoyang, P.R. China (X.-J.Q.)
Xiang-Jun Qiu
Testing and Analysis Laboratory for Phase I Clinical Trials (G.-X.H., P.-P.P., S.-H.W., T.X., J.L.) and Second Affiliated Hospital and Yuying Children's Hospital (Z.-S.W., G.-H.Z., Q.-Q.L., R.-S.G.), Wenzhou Medical University, Wenzhou, P.R. China; Department of Pharmacy, Beijing Hospital, Ministry of Health, Beijing, P.R. China (L.-P.Y.); Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, P.R. China (D.-P.D., J.-P.C.); and Medical College of Henan University of Science and Technology, Luoyang, P.R. China (X.-J.Q.)
Tao Xu
Testing and Analysis Laboratory for Phase I Clinical Trials (G.-X.H., P.-P.P., S.-H.W., T.X., J.L.) and Second Affiliated Hospital and Yuying Children's Hospital (Z.-S.W., G.-H.Z., Q.-Q.L., R.-S.G.), Wenzhou Medical University, Wenzhou, P.R. China; Department of Pharmacy, Beijing Hospital, Ministry of Health, Beijing, P.R. China (L.-P.Y.); Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, P.R. China (D.-P.D., J.-P.C.); and Medical College of Henan University of Science and Technology, Luoyang, P.R. China (X.-J.Q.)
Jun Luo
Testing and Analysis Laboratory for Phase I Clinical Trials (G.-X.H., P.-P.P., S.-H.W., T.X., J.L.) and Second Affiliated Hospital and Yuying Children's Hospital (Z.-S.W., G.-H.Z., Q.-Q.L., R.-S.G.), Wenzhou Medical University, Wenzhou, P.R. China; Department of Pharmacy, Beijing Hospital, Ministry of Health, Beijing, P.R. China (L.-P.Y.); Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, P.R. China (D.-P.D., J.-P.C.); and Medical College of Henan University of Science and Technology, Luoyang, P.R. China (X.-J.Q.)
Qing-Quan Lian
Testing and Analysis Laboratory for Phase I Clinical Trials (G.-X.H., P.-P.P., S.-H.W., T.X., J.L.) and Second Affiliated Hospital and Yuying Children's Hospital (Z.-S.W., G.-H.Z., Q.-Q.L., R.-S.G.), Wenzhou Medical University, Wenzhou, P.R. China; Department of Pharmacy, Beijing Hospital, Ministry of Health, Beijing, P.R. China (L.-P.Y.); Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, P.R. China (D.-P.D., J.-P.C.); and Medical College of Henan University of Science and Technology, Luoyang, P.R. China (X.-J.Q.)
Ren-Shan Ge
Testing and Analysis Laboratory for Phase I Clinical Trials (G.-X.H., P.-P.P., S.-H.W., T.X., J.L.) and Second Affiliated Hospital and Yuying Children's Hospital (Z.-S.W., G.-H.Z., Q.-Q.L., R.-S.G.), Wenzhou Medical University, Wenzhou, P.R. China; Department of Pharmacy, Beijing Hospital, Ministry of Health, Beijing, P.R. China (L.-P.Y.); Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, P.R. China (D.-P.D., J.-P.C.); and Medical College of Henan University of Science and Technology, Luoyang, P.R. China (X.-J.Q.)
Jian-Ping Cai
Testing and Analysis Laboratory for Phase I Clinical Trials (G.-X.H., P.-P.P., S.-H.W., T.X., J.L.) and Second Affiliated Hospital and Yuying Children's Hospital (Z.-S.W., G.-H.Z., Q.-Q.L., R.-S.G.), Wenzhou Medical University, Wenzhou, P.R. China; Department of Pharmacy, Beijing Hospital, Ministry of Health, Beijing, P.R. China (L.-P.Y.); Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, P.R. China (D.-P.D., J.-P.C.); and Medical College of Henan University of Science and Technology, Luoyang, P.R. China (X.-J.Q.)
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Research ArticleArticle
Study for Novel CYP2C9 Variants
Guo-Xin Hu, Pei-Pei Pan, Zeng-Shou Wang, Li-Ping Yang, Da-Peng Dai, Shuang-Hu Wang, Guang-Hui Zhu, Xiang-Jun Qiu, Tao Xu, Jun Luo, Qing-Quan Lian, Ren-Shan Ge and Jian-Ping Cai
Drug Metabolism and Disposition April 1, 2015, 43 (4) 561-569; DOI: https://doi.org/10.1124/dmd.114.061200
Research ArticleArticle
Study for Novel CYP2C9 Variants
Guo-Xin Hu, Pei-Pei Pan, Zeng-Shou Wang, Li-Ping Yang, Da-Peng Dai, Shuang-Hu Wang, Guang-Hui Zhu, Xiang-Jun Qiu, Tao Xu, Jun Luo, Qing-Quan Lian, Ren-Shan Ge and Jian-Ping Cai
Drug Metabolism and Disposition April 1, 2015, 43 (4) 561-569; DOI: https://doi.org/10.1124/dmd.114.061200
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